A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysacch...

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Main Authors: Christian M. Harding, Mohamed A. Nasr, Nichollas E. Scott, Guillaume Goyette-Desjardins, Harald Nothaft, Anne E. Mayer, Sthefany M. Chavez, Jeremy P. Huynh, Rachel L. Kinsella, Christine M. Szymanski, Christina L. Stallings, Mariela Segura, Mario F. Feldman
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
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https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c

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