Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan
Abstract Our study aimed to investigate the incidence, risk factors and time to occurrence of malignancy in patients with dermatomyositis (DM) and polymyositis (PM). The electronic medical records of 1100 patients with DM and 1164 patients with PM were studied between January 2001 and May 2019. Mali...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/defbc33dadc14e5ea14af2dc71c8cb62 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:defbc33dadc14e5ea14af2dc71c8cb62 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:defbc33dadc14e5ea14af2dc71c8cb622021-12-02T13:35:04ZReappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan10.1038/s41598-021-83729-52045-2322https://doaj.org/article/defbc33dadc14e5ea14af2dc71c8cb622021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83729-5https://doaj.org/toc/2045-2322Abstract Our study aimed to investigate the incidence, risk factors and time to occurrence of malignancy in patients with dermatomyositis (DM) and polymyositis (PM). The electronic medical records of 1100 patients with DM and 1164 patients with PM were studied between January 2001 and May 2019. Malignancies after myositis were diagnosed in 61 (5.55%) patients with DM and 38 (3.26%) patients with PM. The cumulative incidence of malignancies in patients with DM were significantly higher than patients with PM (hazard ratio = 1.78, log-rank p = 0.004). Patients with DM had a greater risk of developing malignancy than those with PM at 40–59 years old (p = 0.01). Most malignancies occurred within 1 year after the initial diagnosis of DM (n = 35; 57.38%). Nasopharyngeal cancer (NPC) was the most common type of malignancy in patients with DM (22.95%), followed by lung, and breast cancers. In patients with PM, colorectal, lung and hepatic malignancies were the top three types of malignancy. The risk factors for malignancy included old age (≥ 45 years old) and low serum levels of creatine phosphokinase (CPK) for patients with DM and male sex and low serum levels of CPK for patients with PM. Low serum levels of CPK in patients with myositis with malignancy represented a low degree of muscle destruction/inflammation, which might be attributed to activation of the PD-L1 pathway by tumor cells, thus inducing T-cell dysfunction mediating immune responses in myofibers. A treatment and follow-up algorithm should explore the occurrence of malignancy in different tissues and organs and suggested annual follow-ups for at least 5.5 years to cover the 80% cumulative incidence of malignancy in patients with DM and PM.Jung-Lung HsuMing-Feng LiaoChun-Che ChuHung-Chou KuoRong-Kuo LyuHong-Shiu ChangChiung-Mei ChenYih-Ru WuKuo-Hsuan ChangYi-Ching WengChun-Wei ChangHsing-I. ChiangChih-Kuang ChengPai-Wei LeeChin-Chang HuangLong-Sun RoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jung-Lung Hsu Ming-Feng Liao Chun-Che Chu Hung-Chou Kuo Rong-Kuo Lyu Hong-Shiu Chang Chiung-Mei Chen Yih-Ru Wu Kuo-Hsuan Chang Yi-Ching Weng Chun-Wei Chang Hsing-I. Chiang Chih-Kuang Cheng Pai-Wei Lee Chin-Chang Huang Long-Sun Ro Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| description |
Abstract Our study aimed to investigate the incidence, risk factors and time to occurrence of malignancy in patients with dermatomyositis (DM) and polymyositis (PM). The electronic medical records of 1100 patients with DM and 1164 patients with PM were studied between January 2001 and May 2019. Malignancies after myositis were diagnosed in 61 (5.55%) patients with DM and 38 (3.26%) patients with PM. The cumulative incidence of malignancies in patients with DM were significantly higher than patients with PM (hazard ratio = 1.78, log-rank p = 0.004). Patients with DM had a greater risk of developing malignancy than those with PM at 40–59 years old (p = 0.01). Most malignancies occurred within 1 year after the initial diagnosis of DM (n = 35; 57.38%). Nasopharyngeal cancer (NPC) was the most common type of malignancy in patients with DM (22.95%), followed by lung, and breast cancers. In patients with PM, colorectal, lung and hepatic malignancies were the top three types of malignancy. The risk factors for malignancy included old age (≥ 45 years old) and low serum levels of creatine phosphokinase (CPK) for patients with DM and male sex and low serum levels of CPK for patients with PM. Low serum levels of CPK in patients with myositis with malignancy represented a low degree of muscle destruction/inflammation, which might be attributed to activation of the PD-L1 pathway by tumor cells, thus inducing T-cell dysfunction mediating immune responses in myofibers. A treatment and follow-up algorithm should explore the occurrence of malignancy in different tissues and organs and suggested annual follow-ups for at least 5.5 years to cover the 80% cumulative incidence of malignancy in patients with DM and PM. |
| format |
article |
| author |
Jung-Lung Hsu Ming-Feng Liao Chun-Che Chu Hung-Chou Kuo Rong-Kuo Lyu Hong-Shiu Chang Chiung-Mei Chen Yih-Ru Wu Kuo-Hsuan Chang Yi-Ching Weng Chun-Wei Chang Hsing-I. Chiang Chih-Kuang Cheng Pai-Wei Lee Chin-Chang Huang Long-Sun Ro |
| author_facet |
Jung-Lung Hsu Ming-Feng Liao Chun-Che Chu Hung-Chou Kuo Rong-Kuo Lyu Hong-Shiu Chang Chiung-Mei Chen Yih-Ru Wu Kuo-Hsuan Chang Yi-Ching Weng Chun-Wei Chang Hsing-I. Chiang Chih-Kuang Cheng Pai-Wei Lee Chin-Chang Huang Long-Sun Ro |
| author_sort |
Jung-Lung Hsu |
| title |
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| title_short |
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| title_full |
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| title_fullStr |
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| title_full_unstemmed |
Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan |
| title_sort |
reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in taiwan |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/defbc33dadc14e5ea14af2dc71c8cb62 |
| work_keys_str_mv |
AT junglunghsu reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT mingfengliao reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT chunchechu reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT hungchoukuo reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT rongkuolyu reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT hongshiuchang reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT chiungmeichen reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT yihruwu reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT kuohsuanchang reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT yichingweng reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT chunweichang reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT hsingichiang reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT chihkuangcheng reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT paiweilee reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT chinchanghuang reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan AT longsunro reappraisaloftheincidencevarioustypesandriskfactorsofmalignanciesinpatientswithdermatomyositisandpolymyositisintaiwan |
| _version_ |
1718392705942290432 |