Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

Abstract Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia–ischemia (HI) severely compromi...

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Autores principales:	Ismail S. Zaitoun, Pawan K. Shahi, Andrew Suscha, Kore Chan, Gillian J. McLellan, Bikash R. Pattnaik, Christine M. Sorenson, Nader Sheibani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/defc15708d154c2694a7566ad8ecf618
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spelling	oai:doaj.org-article:defc15708d154c2694a7566ad8ecf6182021-12-02T17:24:22ZHypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina10.1038/s41598-021-90447-52045-2322https://doaj.org/article/defc15708d154c2694a7566ad8ecf6182021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90447-5https://doaj.org/toc/2045-2322Abstract Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia–ischemia (HI) severely compromises the integrity of the retinal neurovasculature, it is not known whether juvenile mice are similarly impacted. Here we examined the effect of HI injury in juvenile mice on retinal structure and function, in particular the susceptibility of retinal neurons and blood vessels to HI damage. Our studies demonstrated that the retina suffered from functional and structural injuries, including reduced b-wave, thinning of the inner retinal layers, macroglial remodeling, and deterioration of the vasculature. The degeneration of the retinal vasculature associated with HI resulted in a significant decrease in the numbers of pericytes and endothelial cells as well as an increase in capillary loss. Taken together, these findings suggest a need for juveniles suffering from ischemic stroke to be monitored for changes in retinal functional and structural integrity. Thus, there is an emergent need for developing therapeutic approaches to prevent and reverse retinal neurovascular dysfunction with exposure to ischemic stroke.Ismail S. ZaitounPawan K. ShahiAndrew SuschaKore ChanGillian J. McLellanBikash R. PattnaikChristine M. SorensonNader SheibaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ismail S. Zaitoun Pawan K. Shahi Andrew Suscha Kore Chan Gillian J. McLellan Bikash R. Pattnaik Christine M. Sorenson Nader Sheibani Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
description	Abstract Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia–ischemia (HI) severely compromises the integrity of the retinal neurovasculature, it is not known whether juvenile mice are similarly impacted. Here we examined the effect of HI injury in juvenile mice on retinal structure and function, in particular the susceptibility of retinal neurons and blood vessels to HI damage. Our studies demonstrated that the retina suffered from functional and structural injuries, including reduced b-wave, thinning of the inner retinal layers, macroglial remodeling, and deterioration of the vasculature. The degeneration of the retinal vasculature associated with HI resulted in a significant decrease in the numbers of pericytes and endothelial cells as well as an increase in capillary loss. Taken together, these findings suggest a need for juveniles suffering from ischemic stroke to be monitored for changes in retinal functional and structural integrity. Thus, there is an emergent need for developing therapeutic approaches to prevent and reverse retinal neurovascular dysfunction with exposure to ischemic stroke.
format	article
author	Ismail S. Zaitoun Pawan K. Shahi Andrew Suscha Kore Chan Gillian J. McLellan Bikash R. Pattnaik Christine M. Sorenson Nader Sheibani
author_facet	Ismail S. Zaitoun Pawan K. Shahi Andrew Suscha Kore Chan Gillian J. McLellan Bikash R. Pattnaik Christine M. Sorenson Nader Sheibani
author_sort	Ismail S. Zaitoun
title	Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
title_short	Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
title_full	Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
title_fullStr	Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
title_full_unstemmed	Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
title_sort	hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/defc15708d154c2694a7566ad8ecf618
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Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

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