Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation

Conrad Waddington famously used his epigenetic landscape to describe the paths a cell might take during developmental differentiation. In this analogy, the undifferentiated stem cell begins at the highest elevation and proceeds to tumble downward towards its final resting place, representing termina...

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Autores principales:	Fanju W. Meng, Patrick J. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/defecbbb3de94f43a44509e7439a4b62
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spelling	oai:doaj.org-article:defecbbb3de94f43a44509e7439a4b622021-12-02T15:45:15ZRolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation10.1038/s42003-021-02154-62399-3642https://doaj.org/article/defecbbb3de94f43a44509e7439a4b622021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02154-6https://doaj.org/toc/2399-3642Conrad Waddington famously used his epigenetic landscape to describe the paths a cell might take during developmental differentiation. In this analogy, the undifferentiated stem cell begins at the highest elevation and proceeds to tumble downward towards its final resting place, representing terminal differentiation. This general concept elegantly captures the essence of developmental transitions, but recent single-cell studies by Dr. Joanna Wysocka’s research group indicate that an alternative strategy underlies development of cranial neural crest cells. Published in Science, Antoine Zalc, Rahul Sinha and colleagues discovered that ectoderm-derived cranial neural crest cells undergo a developmental reprogramming event in vivo, expanding their differentiation potential through the reactivation of pluripotency, in effect rolling backwards up Waddington’s development landscape before eventually differentiating into mesenchymal lineages.Fanju W. MengPatrick J. MurphyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Fanju W. Meng Patrick J. Murphy Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
description	Conrad Waddington famously used his epigenetic landscape to describe the paths a cell might take during developmental differentiation. In this analogy, the undifferentiated stem cell begins at the highest elevation and proceeds to tumble downward towards its final resting place, representing terminal differentiation. This general concept elegantly captures the essence of developmental transitions, but recent single-cell studies by Dr. Joanna Wysocka’s research group indicate that an alternative strategy underlies development of cranial neural crest cells. Published in Science, Antoine Zalc, Rahul Sinha and colleagues discovered that ectoderm-derived cranial neural crest cells undergo a developmental reprogramming event in vivo, expanding their differentiation potential through the reactivation of pluripotency, in effect rolling backwards up Waddington’s development landscape before eventually differentiating into mesenchymal lineages.
format	article
author	Fanju W. Meng Patrick J. Murphy
author_facet	Fanju W. Meng Patrick J. Murphy
author_sort	Fanju W. Meng
title	Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
title_short	Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
title_full	Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
title_fullStr	Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
title_full_unstemmed	Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
title_sort	rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/defecbbb3de94f43a44509e7439a4b62
work_keys_str_mv	AT fanjuwmeng rollinguphillinvivoreacquisitionofpluripotencyduringcranialneuralcrestdifferentiation AT patrickjmurphy rollinguphillinvivoreacquisitionofpluripotencyduringcranialneuralcrestdifferentiation
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Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation

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