The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of...

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Autores principales: Guang Yang, Xinyu Weng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, Peng Wang, LeiLei Ma, Xiaolei Sun, Lei Hou, Huihui Xu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu, Aijun Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/defedf8823f54aecb46bc1b1f72eb945
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spelling oai:doaj.org-article:defedf8823f54aecb46bc1b1f72eb9452021-12-02T17:01:17ZThe histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction10.1038/ncomms149412041-1723https://doaj.org/article/defedf8823f54aecb46bc1b1f72eb9452017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14941https://doaj.org/toc/2041-1723The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.Guang YangXinyu WengYuhao ZhaoXinjian ZhangYuanping HuXin DaiPeng LiangPeng WangLeiLei MaXiaolei SunLei HouHuihui XuMingming FangYuehua LiThomas JenuweinYong XuAijun SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guang Yang
Xinyu Weng
Yuhao Zhao
Xinjian Zhang
Yuanping Hu
Xin Dai
Peng Liang
Peng Wang
LeiLei Ma
Xiaolei Sun
Lei Hou
Huihui Xu
Mingming Fang
Yuehua Li
Thomas Jenuwein
Yong Xu
Aijun Sun
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
description The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.
format article
author Guang Yang
Xinyu Weng
Yuhao Zhao
Xinjian Zhang
Yuanping Hu
Xin Dai
Peng Liang
Peng Wang
LeiLei Ma
Xiaolei Sun
Lei Hou
Huihui Xu
Mingming Fang
Yuehua Li
Thomas Jenuwein
Yong Xu
Aijun Sun
author_facet Guang Yang
Xinyu Weng
Yuhao Zhao
Xinjian Zhang
Yuanping Hu
Xin Dai
Peng Liang
Peng Wang
LeiLei Ma
Xiaolei Sun
Lei Hou
Huihui Xu
Mingming Fang
Yuehua Li
Thomas Jenuwein
Yong Xu
Aijun Sun
author_sort Guang Yang
title The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
title_short The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
title_full The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
title_fullStr The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
title_full_unstemmed The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
title_sort histone h3k9 methyltransferase suv39h links sirt1 repression to myocardial infarction
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/defedf8823f54aecb46bc1b1f72eb945
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