Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases

Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases

Abstract The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to conversion with commonly used recombinant...

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Autores principales: Tze How Mok, Akin Nihat, Connie Luk, Danielle Sequeira, Mark Batchelor, Simon Mead, John Collinge, Graham S. Jackson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/df04884ac887422694fcb1d5a25cc4e0
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