Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation of pathway enzymes and supplementation with metab...

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Autores principales:	Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Adam Antebi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee62
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spelling	oai:doaj.org-article:df062d6b3abf45a7848081ae8c84ee622021-12-02T17:52:19ZRegulation of the one carbon folate cycle as a shared metabolic signature of longevity10.1038/s41467-021-23856-92041-1723https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee622021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23856-9https://doaj.org/toc/2041-1723Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation of pathway enzymes and supplementation with metabolites indicates that they causally regulate longevity.Andrea AnnibalRebecca George TharyanMaribel Fides SchonewolffHannah TamChristian LatzaMarkus Max Karl AulerAdam AntebiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea Annibal Rebecca George Tharyan Maribel Fides Schonewolff Hannah Tam Christian Latza Markus Max Karl Auler Adam Antebi Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
description	Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation of pathway enzymes and supplementation with metabolites indicates that they causally regulate longevity.
format	article
author	Andrea Annibal Rebecca George Tharyan Maribel Fides Schonewolff Hannah Tam Christian Latza Markus Max Karl Auler Adam Antebi
author_facet	Andrea Annibal Rebecca George Tharyan Maribel Fides Schonewolff Hannah Tam Christian Latza Markus Max Karl Auler Adam Antebi
author_sort	Andrea Annibal
title	Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
title_short	Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
title_full	Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
title_fullStr	Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
title_full_unstemmed	Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
title_sort	regulation of the one carbon folate cycle as a shared metabolic signature of longevity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df062d6b3abf45a7848081ae8c84ee62
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Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

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