Structural variant evolution after telomere crisis

Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis and BFB cycles could have emerged from telome...

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Autores principales:	Sally M. Dewhurst, Xiaotong Yao, Joel Rosiene, Huasong Tian, Julie Behr, Nazario Bosco, Kaori K. Takai, Titia de Lange, Marcin Imieliński
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df07fee0b7114bef9405a63b5e335004
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spelling	oai:doaj.org-article:df07fee0b7114bef9405a63b5e3350042021-12-02T14:21:15ZStructural variant evolution after telomere crisis10.1038/s41467-021-21933-72041-1723https://doaj.org/article/df07fee0b7114bef9405a63b5e3350042021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21933-7https://doaj.org/toc/2041-1723Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis and BFB cycles could have emerged from telomere crisis.Sally M. DewhurstXiaotong YaoJoel RosieneHuasong TianJulie BehrNazario BoscoKaori K. TakaiTitia de LangeMarcin ImielińskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sally M. Dewhurst Xiaotong Yao Joel Rosiene Huasong Tian Julie Behr Nazario Bosco Kaori K. Takai Titia de Lange Marcin Imieliński Structural variant evolution after telomere crisis
description	Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis and BFB cycles could have emerged from telomere crisis.
format	article
author	Sally M. Dewhurst Xiaotong Yao Joel Rosiene Huasong Tian Julie Behr Nazario Bosco Kaori K. Takai Titia de Lange Marcin Imieliński
author_facet	Sally M. Dewhurst Xiaotong Yao Joel Rosiene Huasong Tian Julie Behr Nazario Bosco Kaori K. Takai Titia de Lange Marcin Imieliński
author_sort	Sally M. Dewhurst
title	Structural variant evolution after telomere crisis
title_short	Structural variant evolution after telomere crisis
title_full	Structural variant evolution after telomere crisis
title_fullStr	Structural variant evolution after telomere crisis
title_full_unstemmed	Structural variant evolution after telomere crisis
title_sort	structural variant evolution after telomere crisis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df07fee0b7114bef9405a63b5e335004
work_keys_str_mv	AT sallymdewhurst structuralvariantevolutionaftertelomerecrisis AT xiaotongyao structuralvariantevolutionaftertelomerecrisis AT joelrosiene structuralvariantevolutionaftertelomerecrisis AT huasongtian structuralvariantevolutionaftertelomerecrisis AT juliebehr structuralvariantevolutionaftertelomerecrisis AT nazariobosco structuralvariantevolutionaftertelomerecrisis AT kaoriktakai structuralvariantevolutionaftertelomerecrisis AT titiadelange structuralvariantevolutionaftertelomerecrisis AT marcinimielinski structuralvariantevolutionaftertelomerecrisis
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Structural variant evolution after telomere crisis

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