Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform

Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutra...

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Autores principales:	Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df0cbf9ed7ce4cb899492b5771e12516
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spelling	oai:doaj.org-article:df0cbf9ed7ce4cb899492b5771e125162021-12-02T15:39:16ZDevelopment of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform10.1038/s41467-020-19819-12041-1723https://doaj.org/article/df0cbf9ed7ce4cb899492b5771e125162020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19819-1https://doaj.org/toc/2041-1723Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.Flavia ChiuppesiMarcela d’Alincourt SalazarHeidi ContrerasVu H. NguyenJoy MartinezYoonsuh ParkJenny NguyenMindy KhaAngelina IniguezQiao ZhouTeodora KaltchevaRoman LevytskyyNancy D. EbeltTae Hyuk KangXiwei WuThomas F. RogersEdwin R. ManuelYuriy ShostakDon J. DiamondFelix WussowNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Flavia Chiuppesi Marcela d’Alincourt Salazar Heidi Contreras Vu H. Nguyen Joy Martinez Yoonsuh Park Jenny Nguyen Mindy Kha Angelina Iniguez Qiao Zhou Teodora Kaltcheva Roman Levytskyy Nancy D. Ebelt Tae Hyuk Kang Xiwei Wu Thomas F. Rogers Edwin R. Manuel Yuriy Shostak Don J. Diamond Felix Wussow Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
description	Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.
format	article
author	Flavia Chiuppesi Marcela d’Alincourt Salazar Heidi Contreras Vu H. Nguyen Joy Martinez Yoonsuh Park Jenny Nguyen Mindy Kha Angelina Iniguez Qiao Zhou Teodora Kaltcheva Roman Levytskyy Nancy D. Ebelt Tae Hyuk Kang Xiwei Wu Thomas F. Rogers Edwin R. Manuel Yuriy Shostak Don J. Diamond Felix Wussow
author_facet	Flavia Chiuppesi Marcela d’Alincourt Salazar Heidi Contreras Vu H. Nguyen Joy Martinez Yoonsuh Park Jenny Nguyen Mindy Kha Angelina Iniguez Qiao Zhou Teodora Kaltcheva Roman Levytskyy Nancy D. Ebelt Tae Hyuk Kang Xiwei Wu Thomas F. Rogers Edwin R. Manuel Yuriy Shostak Don J. Diamond Felix Wussow
author_sort	Flavia Chiuppesi
title	Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
title_short	Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
title_full	Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
title_fullStr	Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
title_full_unstemmed	Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
title_sort	development of a multi-antigenic sars-cov-2 vaccine candidate using a synthetic poxvirus platform
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/df0cbf9ed7ce4cb899492b5771e12516
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Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform

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