Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds

Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV met...

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Autores principales:	Pavlo Virych, Oksana Nadtoka, Volodymyr Doroschuk, Sergey Lelyushok, Vasyl Chumachenko, Tetiana Bezugla, Nataliya Kutsevol
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/df0d8889df8e481c8a575c6b930878ea
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spelling	oai:doaj.org-article:df0d8889df8e481c8a575c6b930878ea2021-11-22T01:09:48ZCefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds1687-943010.1155/2021/4935642https://doaj.org/article/df0d8889df8e481c8a575c6b930878ea2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4935642https://doaj.org/toc/1687-9430Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.Pavlo VirychOksana NadtokaVolodymyr DoroschukSergey LelyushokVasyl ChumachenkoTetiana BezuglaNataliya KutsevolHindawi LimitedarticleChemical technologyTP1-1185ENInternational Journal of Polymer Science, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical technology TP1-1185
spellingShingle	Chemical technology TP1-1185 Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
description	Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.
format	article
author	Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol
author_facet	Pavlo Virych Oksana Nadtoka Volodymyr Doroschuk Sergey Lelyushok Vasyl Chumachenko Tetiana Bezugla Nataliya Kutsevol
author_sort	Pavlo Virych
title	Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
title_short	Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
title_full	Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
title_fullStr	Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
title_full_unstemmed	Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds
title_sort	cefuroxime-loaded hydrogels for prevention and treatment of bacterial contamination of open wounds
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/df0d8889df8e481c8a575c6b930878ea
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Cefuroxime-Loaded Hydrogels for Prevention and Treatment of Bacterial Contamination of Open Wounds

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