Screening of Chemical Libraries for New Antifungal Drugs against <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

Screening of Chemical Libraries for New Antifungal Drugs against <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

ABSTRACT Aspergillus fumigatus is an important fungal pathogen and the main etiological agent of aspergillosis, a disease characterized by a noninvasive process that can evolve to a more severe clinical manifestation, called invasive pulmonary aspergillosis (IPA), in immunocompromised patients. The...

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Main Authors: Thaila Fernanda dos Reis, Maria Augusta Crivelente Horta, Ana Cristina Colabardini, Caroline Mota Fernandes, Lilian Pereira Silva, Rafael Wesley Bastos, Maria Vitória de Lazari Fonseca, Fang Wang, Celso Martins, Márcio L. Rodrigues, Cristina Silva Pereira, Maurizio Del Poeta, Koon Ho Wong, Gustavo H. Goldman
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Aspergillus fumigatus
drug repurposing
miltefosine
sphingolipids
transcription factor
Microbiology
QR1-502
Online Access:https://doaj.org/article/df0e79e5ab2e41ef86dd3dc64c5b821a
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