Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections

Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer f...

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Autores principales:	Miriam E. van Gent, Muhanad Ali, Peter H. Nibbering, Sylvia N. Kłodzińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/df0fbd4b3f4540caadbd692f74d4a5a6
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spelling	oai:doaj.org-article:df0fbd4b3f4540caadbd692f74d4a5a62021-11-25T18:41:04ZCurrent Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections10.3390/pharmaceutics131118401999-4923https://doaj.org/article/df0fbd4b3f4540caadbd692f74d4a5a62021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1840https://doaj.org/toc/1999-4923Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.Miriam E. van GentMuhanad AliPeter H. NibberingSylvia N. KłodzińskaMDPI AGarticleantimicrobial peptidedrug delivery systemliposomePLGA nanoparticlenanogelantimicrobial coatingPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1840, p 1840 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating Pharmacy and materia medica RS1-441
spellingShingle	antimicrobial peptide drug delivery system liposome PLGA nanoparticle nanogel antimicrobial coating Pharmacy and materia medica RS1-441 Miriam E. van Gent Muhanad Ali Peter H. Nibbering Sylvia N. Kłodzińska Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
description	Bacterial infections constitute a threat to public health as antibiotics are becoming less effective due to the emergence of antimicrobial resistant strains and biofilm and persister formation. Antimicrobial peptides (AMPs) are considered excellent alternatives to antibiotics; however, they suffer from limitations related to their peptidic nature and possible toxicity. The present review critically evaluates the chemical characteristics and antibacterial effects of lipid and polymeric AMP delivery systems and coatings that offer the promise of enhancing the efficacy of AMPs, reducing their limitations and prolonging their half-life. Unfortunately, the antibacterial activities of these systems and coatings have mainly been evaluated in vitro against planktonic bacteria in less biologically relevant conditions, with only some studies focusing on the antibiofilm activities of the formulated AMPs and on the antibacterial effects in animal models. Further improvements of lipid and polymeric AMP delivery systems and coatings may involve the functionalization of these systems to better target the infections and an analysis of the antibacterial activities in biologically relevant environments. Based on the available data we proposed which polymeric AMP delivery system or coatings could be profitable for the treatment of the different hard-to-treat infections, such as bloodstream infections and catheter- or implant-related infections.
format	article
author	Miriam E. van Gent Muhanad Ali Peter H. Nibbering Sylvia N. Kłodzińska
author_facet	Miriam E. van Gent Muhanad Ali Peter H. Nibbering Sylvia N. Kłodzińska
author_sort	Miriam E. van Gent
title	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
title_short	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
title_full	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
title_fullStr	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
title_full_unstemmed	Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections
title_sort	current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/df0fbd4b3f4540caadbd692f74d4a5a6
work_keys_str_mv	AT miriamevangent currentadvancesinlipidandpolymericantimicrobialpeptidedeliverysystemsandcoatingsforthepreventionandtreatmentofbacterialinfections AT muhanadali currentadvancesinlipidandpolymericantimicrobialpeptidedeliverysystemsandcoatingsforthepreventionandtreatmentofbacterialinfections AT peterhnibbering currentadvancesinlipidandpolymericantimicrobialpeptidedeliverysystemsandcoatingsforthepreventionandtreatmentofbacterialinfections AT sylviankłodzinska currentadvancesinlipidandpolymericantimicrobialpeptidedeliverysystemsandcoatingsforthepreventionandtreatmentofbacterialinfections
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Current Advances in Lipid and Polymeric Antimicrobial Peptide Delivery Systems and Coatings for the Prevention and Treatment of Bacterial Infections

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