$Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients$
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Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients

Ji-Youn Kim,1 Hyun Chul Song,1 Hyeon-Gun Jee21Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 2Healthcare Innovation Park, Seoul National University Bundang H...

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Autores principales:	Kim JY, Song HC, Jee HG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	osteomyelitis medication related osteonecrosis of the jaws osteonecrosis recurrence diabetes mellitus steroid Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/df13e04e3ff44be7b4ca916095c9fc75
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spelling	oai:doaj.org-article:df13e04e3ff44be7b4ca916095c9fc752021-12-02T03:17:43ZRefractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients1178-1998https://doaj.org/article/df13e04e3ff44be7b4ca916095c9fc752019-05-01T00:00:00Zhttps://www.dovepress.com/refractory-healing-after-surgical-therapy-of-osteonecrosis-of-the-jaw--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ji-Youn Kim,1 Hyun Chul Song,1 Hyeon-Gun Jee21Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 2Healthcare Innovation Park, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaPurpose: Osteonecrosis of the jaw (ONJ), both medication-related and non medication-related, mainly occurs in aged patients. It needs surgical intervention. Refractory healing after an operation of ONJ can significantly lower the quality of life of elderly patients. The purpose of this study was to determine risk factors associated with refractory healing in aged patients.Patients and methods: We performed a retrospective study of ONJ in aged patients who underwent surgical treatments in a single institute during a 12-year period. Multiple logistic regression analysis was used to determine independent risk factors associated with refractory healing.Results: A total of 122 patients were included. Of them, 25 patients were identified as the refractory group and 97 patients as the control group. Diabetes mellitus (DM) (AOR=5.03, 95% CI: 1.74–14.52) and glucocorticoid administration (AOR=7.97, 95% CI: 2.52–25.23) were found to be significant risk factors for refractory healing of ONJ.Conclusion: DM and medication of glucocorticoid might be risk factors for refractory healing of ONJ.Keywords: osteomyelitis, osteonecrosis, medication-related osteonecrosis of the jaw, surgical therapy, refractory healing, diabetes mellitus, glucocorticoidKim JYSong HCJee HGDove Medical Pressarticleosteomyelitismedication related osteonecrosis of the jawsosteonecrosisrecurrencediabetes mellitussteroidGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 797-804 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteomyelitis medication related osteonecrosis of the jaws osteonecrosis recurrence diabetes mellitus steroid Geriatrics RC952-954.6
spellingShingle	osteomyelitis medication related osteonecrosis of the jaws osteonecrosis recurrence diabetes mellitus steroid Geriatrics RC952-954.6 Kim JY Song HC Jee HG Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
description	Ji-Youn Kim,1 Hyun Chul Song,1 Hyeon-Gun Jee21Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 2Healthcare Innovation Park, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaPurpose: Osteonecrosis of the jaw (ONJ), both medication-related and non medication-related, mainly occurs in aged patients. It needs surgical intervention. Refractory healing after an operation of ONJ can significantly lower the quality of life of elderly patients. The purpose of this study was to determine risk factors associated with refractory healing in aged patients.Patients and methods: We performed a retrospective study of ONJ in aged patients who underwent surgical treatments in a single institute during a 12-year period. Multiple logistic regression analysis was used to determine independent risk factors associated with refractory healing.Results: A total of 122 patients were included. Of them, 25 patients were identified as the refractory group and 97 patients as the control group. Diabetes mellitus (DM) (AOR=5.03, 95% CI: 1.74–14.52) and glucocorticoid administration (AOR=7.97, 95% CI: 2.52–25.23) were found to be significant risk factors for refractory healing of ONJ.Conclusion: DM and medication of glucocorticoid might be risk factors for refractory healing of ONJ.Keywords: osteomyelitis, osteonecrosis, medication-related osteonecrosis of the jaw, surgical therapy, refractory healing, diabetes mellitus, glucocorticoid
format	article
author	Kim JY Song HC Jee HG
author_facet	Kim JY Song HC Jee HG
author_sort	Kim JY
title	Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
title_short	Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
title_full	Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
title_fullStr	Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
title_full_unstemmed	Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
title_sort	refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/df13e04e3ff44be7b4ca916095c9fc75
work_keys_str_mv	AT kimjy refractoryhealingaftersurgicaltherapyofosteonecrosisofthejawassociatedriskfactorsinagedpatients AT songhc refractoryhealingaftersurgicaltherapyofosteonecrosisofthejawassociatedriskfactorsinagedpatients AT jeehg refractoryhealingaftersurgicaltherapyofosteonecrosisofthejawassociatedriskfactorsinagedpatients
_version_	1718401890058764288

Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients

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