The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences
The uniqueness of structure and physiology of the lymphatic system make it challenging to delineate all its contributions in the maintenance of our health. However, in the past two decades, the understanding of the importance of the function of this system has evolved and more appreciation has been...
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Canadian Society for Pharmaceutical Sciences
2021
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oai:doaj.org-article:df1426da5a1c4021ad3ffc5c2a9ad9262021-12-02T19:40:10ZThe Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences10.18433/jpps322221482-1826https://doaj.org/article/df1426da5a1c4021ad3ffc5c2a9ad9262021-10-01T00:00:00Zhttps://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/32222https://doaj.org/toc/1482-1826 The uniqueness of structure and physiology of the lymphatic system make it challenging to delineate all its contributions in the maintenance of our health. However, in the past two decades, the understanding of the importance of the function of this system has evolved and more appreciation has been drawn to the distinctive role it plays in health and disease. The lymphatic system has been linked to the pathophysiology of numerous ailments including cancer, various metabolic diseases, inflammatory conditions, and infections. Moreover, it has also been revealed that lymphatic targeted formulations can enhance the delivery of drugs through the lymphatic system to the bloodstream, bypassing the hepatic first-pass metabolism if taken orally, thus increasing the bioavailability, and improving the pharmacokinetic and toxicological profiles in general. Engineering lymphotropic preparations requires the understanding of many factors, the most important one being that of the physiological environment which they will encounter. Therefore, in this review, we detail the basic structure of the lymphatic system, then highlight the therapeutic and the pharmacokinetic benefits of drug delivery into the lymphatic system. The criteria for drugs and formulations used for lymphotropic delivery are also detailed with a contemporary overview of various studies undertaken in this field. Malaz YousefDaniela SilvaNadia Bou ChacraNeal DaviesRaimar LöbenbergCanadian Society for Pharmaceutical SciencesarticleTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021) |
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DOAJ |
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Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 |
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Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Malaz Yousef Daniela Silva Nadia Bou Chacra Neal Davies Raimar Löbenberg The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| description |
The uniqueness of structure and physiology of the lymphatic system make it challenging to delineate all its contributions in the maintenance of our health. However, in the past two decades, the understanding of the importance of the function of this system has evolved and more appreciation has been drawn to the distinctive role it plays in health and disease. The lymphatic system has been linked to the pathophysiology of numerous ailments including cancer, various metabolic diseases, inflammatory conditions, and infections. Moreover, it has also been revealed that lymphatic targeted formulations can enhance the delivery of drugs through the lymphatic system to the bloodstream, bypassing the hepatic first-pass metabolism if taken orally, thus increasing the bioavailability, and improving the pharmacokinetic and toxicological profiles in general. Engineering lymphotropic preparations requires the understanding of many factors, the most important one being that of the physiological environment which they will encounter. Therefore, in this review, we detail the basic structure of the lymphatic system, then highlight the therapeutic and the pharmacokinetic benefits of drug delivery into the lymphatic system. The criteria for drugs and formulations used for lymphotropic delivery are also detailed with a contemporary overview of various studies undertaken in this field.
|
| format |
article |
| author |
Malaz Yousef Daniela Silva Nadia Bou Chacra Neal Davies Raimar Löbenberg |
| author_facet |
Malaz Yousef Daniela Silva Nadia Bou Chacra Neal Davies Raimar Löbenberg |
| author_sort |
Malaz Yousef |
| title |
The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| title_short |
The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| title_full |
The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| title_fullStr |
The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| title_full_unstemmed |
The Lymphatic System: A Sometimes-Forgotten Compartment in Pharmaceutical Sciences |
| title_sort |
lymphatic system: a sometimes-forgotten compartment in pharmaceutical sciences |
| publisher |
Canadian Society for Pharmaceutical Sciences |
| publishDate |
2021 |
| url |
https://doaj.org/article/df1426da5a1c4021ad3ffc5c2a9ad926 |
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