Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction

Excessive fructose (Fru) consumption has been reported to favor nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanism is still elusive, lacking effective therapeutic strategies. Carminic acid (CA), a glucosylated anthraquinone found in scale insects like Dactylopius coccus, exer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ling Li, Bo Fang, Yinglei Zhang, Liuqing Yan, Yuxin He, Linfeng Hu, Qifei Xu, Qiang Li, Xianling Dai, Qin Kuang, Minxuan Xu, Jun Tan, Chenxu Ge
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	NAFLD Carminic acid (CA) Dyslipidemia Inflammation Oxidative stress Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/df14459ae6f848ce862ad59f2546c9c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df14459ae6f848ce862ad59f2546c9c6
record_format	dspace
spelling	oai:doaj.org-article:df14459ae6f848ce862ad59f2546c9c62021-11-14T04:30:29ZCarminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction0753-332210.1016/j.biopha.2021.112404https://doaj.org/article/df14459ae6f848ce862ad59f2546c9c62022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011902https://doaj.org/toc/0753-3322Excessive fructose (Fru) consumption has been reported to favor nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanism is still elusive, lacking effective therapeutic strategies. Carminic acid (CA), a glucosylated anthraquinone found in scale insects like Dactylopius coccus, exerts anti-tumor and anti-oxidant activities. Nevertheless, its regulatory role in Fru-induced NAFLD is still obscure. Here, the effects of CA on NAFLD in Fru-challenged mice and the underlying molecular mechanisms were explored. We found that Fru intake significantly led to insulin resistance and dyslipidemia in liver of mice, which were considerably attenuated by CA treatment through repressing endoplasmic reticulum (ER) stress. Additionally, inflammatory response induced by Fru was also attenuated by CA via the blockage of nuclear factor-κB (NF-κB), mitogen-activated protein kinases (MAPKs) and tumor necrosis factor α/TNF-α receptor (TNF-α/TNFRs) signaling pathways. Moreover, Fru-provoked oxidative stress in liver tissues was remarkably attenuated by CA mainly through improving the activation of nuclear factor erythroid 2-related factor 2 (Nrf-2). These anti-dyslipidemias, anti-inflammatory and anti-oxidant activities regulated by CA were confirmed in the isolated primary hepatocytes with Fru stimulation. Importantly, the in vitro experiments demonstrated that Fru-induced lipid accumulation was closely associated with inflammatory response and reactive oxygen species (ROS) production regulated by TNF-α and Nrf-2 signaling pathways, respectively. In conclusion, these results demonstrated that CA could be considered as a potential therapeutic strategy to attenuate metabolic disorder and NAFLD in Fru-challenged mice mainly through suppressing inflammatory response and oxidative stress.Ling LiBo FangYinglei ZhangLiuqing YanYuxin HeLinfeng HuQifei XuQiang LiXianling DaiQin KuangMinxuan XuJun TanChenxu GeElsevierarticleNAFLDCarminic acid (CA)DyslipidemiaInflammationOxidative stressTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112404- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	NAFLD Carminic acid (CA) Dyslipidemia Inflammation Oxidative stress Therapeutics. Pharmacology RM1-950
spellingShingle	NAFLD Carminic acid (CA) Dyslipidemia Inflammation Oxidative stress Therapeutics. Pharmacology RM1-950 Ling Li Bo Fang Yinglei Zhang Liuqing Yan Yuxin He Linfeng Hu Qifei Xu Qiang Li Xianling Dai Qin Kuang Minxuan Xu Jun Tan Chenxu Ge Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
description	Excessive fructose (Fru) consumption has been reported to favor nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanism is still elusive, lacking effective therapeutic strategies. Carminic acid (CA), a glucosylated anthraquinone found in scale insects like Dactylopius coccus, exerts anti-tumor and anti-oxidant activities. Nevertheless, its regulatory role in Fru-induced NAFLD is still obscure. Here, the effects of CA on NAFLD in Fru-challenged mice and the underlying molecular mechanisms were explored. We found that Fru intake significantly led to insulin resistance and dyslipidemia in liver of mice, which were considerably attenuated by CA treatment through repressing endoplasmic reticulum (ER) stress. Additionally, inflammatory response induced by Fru was also attenuated by CA via the blockage of nuclear factor-κB (NF-κB), mitogen-activated protein kinases (MAPKs) and tumor necrosis factor α/TNF-α receptor (TNF-α/TNFRs) signaling pathways. Moreover, Fru-provoked oxidative stress in liver tissues was remarkably attenuated by CA mainly through improving the activation of nuclear factor erythroid 2-related factor 2 (Nrf-2). These anti-dyslipidemias, anti-inflammatory and anti-oxidant activities regulated by CA were confirmed in the isolated primary hepatocytes with Fru stimulation. Importantly, the in vitro experiments demonstrated that Fru-induced lipid accumulation was closely associated with inflammatory response and reactive oxygen species (ROS) production regulated by TNF-α and Nrf-2 signaling pathways, respectively. In conclusion, these results demonstrated that CA could be considered as a potential therapeutic strategy to attenuate metabolic disorder and NAFLD in Fru-challenged mice mainly through suppressing inflammatory response and oxidative stress.
format	article
author	Ling Li Bo Fang Yinglei Zhang Liuqing Yan Yuxin He Linfeng Hu Qifei Xu Qiang Li Xianling Dai Qin Kuang Minxuan Xu Jun Tan Chenxu Ge
author_facet	Ling Li Bo Fang Yinglei Zhang Liuqing Yan Yuxin He Linfeng Hu Qifei Xu Qiang Li Xianling Dai Qin Kuang Minxuan Xu Jun Tan Chenxu Ge
author_sort	Ling Li
title	Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
title_short	Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
title_full	Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
title_fullStr	Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
title_full_unstemmed	Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
title_sort	carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/df14459ae6f848ce862ad59f2546c9c6
work_keys_str_mv	AT lingli carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT bofang carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT yingleizhang carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT liuqingyan carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT yuxinhe carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT linfenghu carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT qifeixu carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT qiangli carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT xianlingdai carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT qinkuang carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT minxuanxu carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT juntan carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction AT chenxuge carminicacidmitigatesfructosetriggeredhepaticsteatosisbyinhibitionofoxidativestressandinflammatoryreaction
_version_	1718429988813799424

Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction

Ejemplares similares