Amino Acid Differences in the 1753-to-1851 Region of TcdB Influence Variations in TcdB1 and TcdB2 Cell Entry
ABSTRACT Clostridium difficile TcdB2 enters cells with a higher efficiency than TcdB1 and exhibits an overall higher level of toxicity. However, the TcdB2-specific sequences that account for more efficient cell entry have not been reported. In this study, we examined the contribution of carboxy-term...
Saved in:
Main Authors: | Jonathan J. Hunt, Jason L. Larabee, Jimmy D. Ballard |
---|---|
Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/df14dd59e50e4d2db5d147652b5f8dc6 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Intrinsic Toxin-Derived Peptides Destabilize and Inactivate <italic toggle="yes">Clostridium difficile</italic> TcdB
by: Jason L. Larabee, et al.
Published: (2017) -
RstA Is a Major Regulator of <named-content content-type="genus-species">Clostridioides difficile</named-content> Toxin Production and Motility
by: Adrianne N. Edwards, et al.
Published: (2019) -
Combined and Distinct Roles of Agr Proteins in <named-content content-type="genus-species">Clostridioides difficile</named-content> 630 Sporulation, Motility, and Toxin Production
by: Ummey Khalecha Bintha Ahmed, et al.
Published: (2020) -
Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues
by: Ashleigh S. Paparella, et al.
Published: (2021) -
The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB
by: Panagiotis Papatheodorou, et al.
Published: (2021)