Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia

Abstract Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and el...

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Autores principales:	Zhen-Peng Mai, Gang Ni, Yan-Fei Liu, Li Li, Guo-Ru Shi, Xin Wang, Jia-Yuan Li, De-Quan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df1a1d5cc02745b89813bc90d448982d
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spelling	oai:doaj.org-article:df1a1d5cc02745b89813bc90d448982d2021-12-02T16:06:14ZHeliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia10.1038/s41598-017-04399-w2045-2322https://doaj.org/article/df1a1d5cc02745b89813bc90d448982d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04399-whttps://doaj.org/toc/2045-2322Abstract Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. The plausible biogenetic pathways of 1 and 2 were postulated. 1 and 2 were found to be potent inhibitors of P-glycoprotein (ABCB1) and 1 also exhibited cytotoxicity against MDA-MB-231 cell lines.Zhen-Peng MaiGang NiYan-Fei LiuLi LiGuo-Ru ShiXin WangJia-Yuan LiDe-Quan YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen-Peng Mai Gang Ni Yan-Fei Liu Li Li Guo-Ru Shi Xin Wang Jia-Yuan Li De-Quan Yu Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
description	Abstract Heliosterpenoids A and B (1 and 2), two unprecedented jatrophane-derived diterpenoid esters with a novel 5/6/4/6-fused tetracyclic ring skeleton, were isolated from the whole plants of Euphorbia helioscopia. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. The plausible biogenetic pathways of 1 and 2 were postulated. 1 and 2 were found to be potent inhibitors of P-glycoprotein (ABCB1) and 1 also exhibited cytotoxicity against MDA-MB-231 cell lines.
format	article
author	Zhen-Peng Mai Gang Ni Yan-Fei Liu Li Li Guo-Ru Shi Xin Wang Jia-Yuan Li De-Quan Yu
author_facet	Zhen-Peng Mai Gang Ni Yan-Fei Liu Li Li Guo-Ru Shi Xin Wang Jia-Yuan Li De-Quan Yu
author_sort	Zhen-Peng Mai
title	Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_short	Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_full	Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_fullStr	Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_full_unstemmed	Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
title_sort	heliosterpenoids a and b, two novel jatrophane-derived diterpenoids with a 5/6/4/6 ring system from euphorbia helioscopia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/df1a1d5cc02745b89813bc90d448982d
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Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia

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