Homeostasis of the ER redox state subsequent to proteasome inhibition

Abstract Endoplasmic reticulum (ER) maintains within, an oxidative redox state suitable for disulfide bond formation. We monitored the ER redox dynamics subsequent to proteasome inhibition using an ER redox probe ERroGFP S4. Proteasomal inhibition initially led to oxidation of the ER, but gradually...

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Autores principales: Yuki Oku, Masahiro Kariya, Takaaki Fujimura, Jun Hoseki, Yasuyoshi Sakai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/df1b35d163c24cf2ac5874699cdd79ea
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