Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showi...

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Autores principales: Cheng-Tao Jiang, Kai-Ge Chen, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/df1fd3f94ada4483a1c1ec207bb754dd
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spelling oai:doaj.org-article:df1fd3f94ada4483a1c1ec207bb754dd2021-12-02T15:52:37ZImmunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy10.1038/s41467-021-21497-62041-1723https://doaj.org/article/df1fd3f94ada4483a1c1ec207bb754dd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21497-6https://doaj.org/toc/2041-1723Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.Cheng-Tao JiangKai-Ge ChenAn LiuHua HuangYa-Nan FanDong-Kun ZhaoQian-Ni YeHou-Bing ZhangCong-Fei XuSong ShenMeng-Hua XiongJin-Zhi DuXian-Zhu YangJun WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cheng-Tao Jiang
Kai-Ge Chen
An Liu
Hua Huang
Ya-Nan Fan
Dong-Kun Zhao
Qian-Ni Ye
Hou-Bing Zhang
Cong-Fei Xu
Song Shen
Meng-Hua Xiong
Jin-Zhi Du
Xian-Zhu Yang
Jun Wang
Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
description Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.
format article
author Cheng-Tao Jiang
Kai-Ge Chen
An Liu
Hua Huang
Ya-Nan Fan
Dong-Kun Zhao
Qian-Ni Ye
Hou-Bing Zhang
Cong-Fei Xu
Song Shen
Meng-Hua Xiong
Jin-Zhi Du
Xian-Zhu Yang
Jun Wang
author_facet Cheng-Tao Jiang
Kai-Ge Chen
An Liu
Hua Huang
Ya-Nan Fan
Dong-Kun Zhao
Qian-Ni Ye
Hou-Bing Zhang
Cong-Fei Xu
Song Shen
Meng-Hua Xiong
Jin-Zhi Du
Xian-Zhu Yang
Jun Wang
author_sort Cheng-Tao Jiang
title Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_short Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_full Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_fullStr Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_full_unstemmed Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
title_sort immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/df1fd3f94ada4483a1c1ec207bb754dd
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AT anliu immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
AT huahuang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
AT yananfan immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
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AT qianniye immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
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AT xianzhuyang immunomodulatingnanoadaptorspotentiateantibodybasedcancerimmunotherapy
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