Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study

Abstract Pharmacovigilance reports of cerebral and cardiovascular events in those who use decongestants have triggered alerts related to their use. We aimed to assess the risk of stroke and myocardial infarction (MI) associated with the use of decongestants. We conducted a nested case-crossover stud...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lamiae Grimaldi-Bensouda, Bernard Begaud, Jacques Benichou, Clementine Nordon, Olivia Dialla, Nicolas Morisot, Yann Hamon, Yves Cottin, Elie Serrano, Lucien Abenhaim, Emmanuel Touzé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df2016a659954236b767621939ce8ec0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df2016a659954236b767621939ce8ec0
record_format	dspace
spelling	oai:doaj.org-article:df2016a659954236b767621939ce8ec02021-12-02T10:54:23ZDecongestant use and the risk of myocardial infarction and stroke: a case-crossover study10.1038/s41598-021-83718-82045-2322https://doaj.org/article/df2016a659954236b767621939ce8ec02021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83718-8https://doaj.org/toc/2045-2322Abstract Pharmacovigilance reports of cerebral and cardiovascular events in those who use decongestants have triggered alerts related to their use. We aimed to assess the risk of stroke and myocardial infarction (MI) associated with the use of decongestants. We conducted a nested case-crossover study of patients with incident stroke and MI identified in France between 2013 and 2016 in two systematic disease registries. Decongestant use in the three weeks preceding the event was assessed using a structured telephone interview. Conditional logistic multivariable models were used to estimate the odds of incident MI and stroke, also accounting for transient risk factors and comparing week 1 (index at-risk time window, immediately preceding the event) to week 3 (reference). Time-invariant risk factors were controlled by design. In total, 1394 patients with MI and 1403 patients with stroke, mainly 70 years old or younger, were interviewed, including 3.2% who used decongestants during the three weeks prior to the event (1.0% definite exposure in the index at-risk time window, 1.1% in the referent time window; adjusted odds ratio (aOR), 0.78; 95%CI, 0.43–1.42). Secondary analysis yielded similar results for individual events (MI/stroke). We observed no increased risk of MI or stroke for patients 70 years of age and younger without previous MI or stroke who used decongestants.Lamiae Grimaldi-BensoudaBernard BegaudJacques BenichouClementine NordonOlivia DiallaNicolas MorisotYann HamonYves CottinElie SerranoLucien AbenhaimEmmanuel TouzéNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lamiae Grimaldi-Bensouda Bernard Begaud Jacques Benichou Clementine Nordon Olivia Dialla Nicolas Morisot Yann Hamon Yves Cottin Elie Serrano Lucien Abenhaim Emmanuel Touzé Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
description	Abstract Pharmacovigilance reports of cerebral and cardiovascular events in those who use decongestants have triggered alerts related to their use. We aimed to assess the risk of stroke and myocardial infarction (MI) associated with the use of decongestants. We conducted a nested case-crossover study of patients with incident stroke and MI identified in France between 2013 and 2016 in two systematic disease registries. Decongestant use in the three weeks preceding the event was assessed using a structured telephone interview. Conditional logistic multivariable models were used to estimate the odds of incident MI and stroke, also accounting for transient risk factors and comparing week 1 (index at-risk time window, immediately preceding the event) to week 3 (reference). Time-invariant risk factors were controlled by design. In total, 1394 patients with MI and 1403 patients with stroke, mainly 70 years old or younger, were interviewed, including 3.2% who used decongestants during the three weeks prior to the event (1.0% definite exposure in the index at-risk time window, 1.1% in the referent time window; adjusted odds ratio (aOR), 0.78; 95%CI, 0.43–1.42). Secondary analysis yielded similar results for individual events (MI/stroke). We observed no increased risk of MI or stroke for patients 70 years of age and younger without previous MI or stroke who used decongestants.
format	article
author	Lamiae Grimaldi-Bensouda Bernard Begaud Jacques Benichou Clementine Nordon Olivia Dialla Nicolas Morisot Yann Hamon Yves Cottin Elie Serrano Lucien Abenhaim Emmanuel Touzé
author_facet	Lamiae Grimaldi-Bensouda Bernard Begaud Jacques Benichou Clementine Nordon Olivia Dialla Nicolas Morisot Yann Hamon Yves Cottin Elie Serrano Lucien Abenhaim Emmanuel Touzé
author_sort	Lamiae Grimaldi-Bensouda
title	Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
title_short	Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
title_full	Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
title_fullStr	Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
title_full_unstemmed	Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
title_sort	decongestant use and the risk of myocardial infarction and stroke: a case-crossover study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df2016a659954236b767621939ce8ec0
work_keys_str_mv	AT lamiaegrimaldibensouda decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT bernardbegaud decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT jacquesbenichou decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT clementinenordon decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT oliviadialla decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT nicolasmorisot decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT yannhamon decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT yvescottin decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT elieserrano decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT lucienabenhaim decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy AT emmanueltouze decongestantuseandtheriskofmyocardialinfarctionandstrokeacasecrossoverstudy
_version_	1718396498953109504

Decongestant use and the risk of myocardial infarction and stroke: a case-crossover study

Ejemplares similares