The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy

Aim. To assess the relationship of glucose variability (GV) and renal function in patients with type 2 diabetes on basal-bolus insulin therapy.Materials and methods. We observed 101 females with type 2 diabetes, aged 47–79 years, with a glomerular filtration rate (GFR) >30 mL/min/1.73 m2. Ins...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vadim V. Klimontov, Natalia E. Myakina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes chronic kidney disease glucose variability continuous glucose monitoring hypoglycaemia Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/df219b43e22042bcace1c7c4c726db70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df219b43e22042bcace1c7c4c726db70
record_format	dspace
spelling	oai:doaj.org-article:df219b43e22042bcace1c7c4c726db702021-11-14T09:00:20ZThe relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy2072-03512072-037810.14341/DM7181https://doaj.org/article/df219b43e22042bcace1c7c4c726db702015-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7181https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To assess the relationship of glucose variability (GV) and renal function in patients with type 2 diabetes on basal-bolus insulin therapy.Materials and methods. We observed 101 females with type 2 diabetes, aged 47–79 years, with a glomerular filtration rate (GFR) >30 mL/min/1.73 m2. Insulin was combined with metformin in 45 of these women. The mean glucose and standard deviation, continuous overlapping net glucose action, lability index, J-index, low blood glucose index (LBGI), high blood glucose index (HBGI), M-value and mean absolute glucose (MAG) were calculated based on the results of blinded continuous glucose monitoring. The prevalence of episodes of low interstitial glucose (<3.9 and 2.8 mmol/L) of at least 20-min duration was estimated.Results. Patients with a GFR of 30–44 mL/min/1.73 m2 had significantly lower HBGI, J-index, MAG and M-value compared with those with better filtration (all p < 0.05); LBGI was not dependent on GFR. The GFR values were weakly and positively correlated with HBGI, J-index, M-value and MAG. Multiple regression analysis showed that GFR is an independent predictor of MAG (p = 0.04). No significant differences were found in the prevalence of episodes of low interstitial glucose between patients with different GFR ranges.Conclusions. GV parameters are related to renal function in type 2 diabetic women on basal-bolus insulin therapy. Patients with stage 3b chronic kidney disease have reduced GV, predominantly in the hyperglycaemic band, compared with those with better filtration.Vadim V. KlimontovNatalia E. MyakinaEndocrinology Research Centrearticletype 2 diabeteschronic kidney diseaseglucose variabilitycontinuous glucose monitoringhypoglycaemiaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 4, Pp 66-71 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes chronic kidney disease glucose variability continuous glucose monitoring hypoglycaemia Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes chronic kidney disease glucose variability continuous glucose monitoring hypoglycaemia Nutritional diseases. Deficiency diseases RC620-627 Vadim V. Klimontov Natalia E. Myakina The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
description	Aim. To assess the relationship of glucose variability (GV) and renal function in patients with type 2 diabetes on basal-bolus insulin therapy.Materials and methods. We observed 101 females with type 2 diabetes, aged 47–79 years, with a glomerular filtration rate (GFR) >30 mL/min/1.73 m2. Insulin was combined with metformin in 45 of these women. The mean glucose and standard deviation, continuous overlapping net glucose action, lability index, J-index, low blood glucose index (LBGI), high blood glucose index (HBGI), M-value and mean absolute glucose (MAG) were calculated based on the results of blinded continuous glucose monitoring. The prevalence of episodes of low interstitial glucose (<3.9 and 2.8 mmol/L) of at least 20-min duration was estimated.Results. Patients with a GFR of 30–44 mL/min/1.73 m2 had significantly lower HBGI, J-index, MAG and M-value compared with those with better filtration (all p < 0.05); LBGI was not dependent on GFR. The GFR values were weakly and positively correlated with HBGI, J-index, M-value and MAG. Multiple regression analysis showed that GFR is an independent predictor of MAG (p = 0.04). No significant differences were found in the prevalence of episodes of low interstitial glucose between patients with different GFR ranges.Conclusions. GV parameters are related to renal function in type 2 diabetic women on basal-bolus insulin therapy. Patients with stage 3b chronic kidney disease have reduced GV, predominantly in the hyperglycaemic band, compared with those with better filtration.
format	article
author	Vadim V. Klimontov Natalia E. Myakina
author_facet	Vadim V. Klimontov Natalia E. Myakina
author_sort	Vadim V. Klimontov
title	The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
title_short	The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
title_full	The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
title_fullStr	The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
title_full_unstemmed	The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
title_sort	relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/df219b43e22042bcace1c7c4c726db70
work_keys_str_mv	AT vadimvklimontov therelationshipsbetweenglucosevariabilityandrenalfunctionintype2diabetespatientsonbasalbolusinsulintherapy AT nataliaemyakina therelationshipsbetweenglucosevariabilityandrenalfunctionintype2diabetespatientsonbasalbolusinsulintherapy AT vadimvklimontov relationshipsbetweenglucosevariabilityandrenalfunctionintype2diabetespatientsonbasalbolusinsulintherapy AT nataliaemyakina relationshipsbetweenglucosevariabilityandrenalfunctionintype2diabetespatientsonbasalbolusinsulintherapy
_version_	1718429559607525376

The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy

Ejemplares similares