Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. Methods: Five experimental groups were cons...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	leishmania rolling cellular adhesion leukocyte Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/df254898b4ba42e19c299a733a3aaf6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df254898b4ba42e19c299a733a3aaf6f
record_format	dspace
spelling	oai:doaj.org-article:df254898b4ba42e19c299a733a3aaf6f2021-11-29T07:18:54ZLeukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice1735-70202008-238Xhttps://doaj.org/article/df254898b4ba42e19c299a733a3aaf6f2021-11-01T00:00:00Zhttps://ijpa.tums.ac.ir/index.php/ijpa/article/view/3303https://doaj.org/toc/1735-7020https://doaj.org/toc/2008-238XBackground: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. Methods: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. Results: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively. Conclusion: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course.Herintha Coeto Neitzke-AbreuRhuan Carlos Souza CaetanoKárin Rosi Reinhold-CastroManoel Sebastião da Costa Lima-JuniorWagner José Tenório dos SantosGessilda de Alcantara Nogueira de MeloRoberto Kenji Nakamura CumanSandra Mara Alessi AristidesThais Gomes Verzignassi SilveiraMaria Valdrinez Campana LonardoniTehran University of Medical Sciencesarticleleishmaniarollingcellular adhesionleukocyteInfectious and parasitic diseasesRC109-216ENIranian Journal of Parasitology, Vol 16, Iss 4, Pp 567-575 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leishmania rolling cellular adhesion leukocyte Infectious and parasitic diseases RC109-216
spellingShingle	leishmania rolling cellular adhesion leukocyte Infectious and parasitic diseases RC109-216 Herintha Coeto Neitzke-Abreu Rhuan Carlos Souza Caetano Kárin Rosi Reinhold-Castro Manoel Sebastião da Costa Lima-Junior Wagner José Tenório dos Santos Gessilda de Alcantara Nogueira de Melo Roberto Kenji Nakamura Cuman Sandra Mara Alessi Aristides Thais Gomes Verzignassi Silveira Maria Valdrinez Campana Lonardoni Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
description	Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. Methods: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. Results: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively. Conclusion: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course.
format	article
author	Herintha Coeto Neitzke-Abreu Rhuan Carlos Souza Caetano Kárin Rosi Reinhold-Castro Manoel Sebastião da Costa Lima-Junior Wagner José Tenório dos Santos Gessilda de Alcantara Nogueira de Melo Roberto Kenji Nakamura Cuman Sandra Mara Alessi Aristides Thais Gomes Verzignassi Silveira Maria Valdrinez Campana Lonardoni
author_facet	Herintha Coeto Neitzke-Abreu Rhuan Carlos Souza Caetano Kárin Rosi Reinhold-Castro Manoel Sebastião da Costa Lima-Junior Wagner José Tenório dos Santos Gessilda de Alcantara Nogueira de Melo Roberto Kenji Nakamura Cuman Sandra Mara Alessi Aristides Thais Gomes Verzignassi Silveira Maria Valdrinez Campana Lonardoni
author_sort	Herintha Coeto Neitzke-Abreu
title	Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
title_short	Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
title_full	Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
title_fullStr	Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
title_full_unstemmed	Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
title_sort	leukocyte behavior in mesenteric microcirculation upon experimental by leishmania spp. in balb/c mice
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/df254898b4ba42e19c299a733a3aaf6f
work_keys_str_mv	AT herinthacoetoneitzkeabreu leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT rhuancarlossouzacaetano leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT karinrosireinholdcastro leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT manoelsebastiaodacostalimajunior leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT wagnerjosetenoriodossantos leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT gessildadealcantaranogueirademelo leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT robertokenjinakamuracuman leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT sandramaraalessiaristides leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT thaisgomesverzignassisilveira leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice AT mariavaldrinezcampanalonardoni leukocytebehaviorinmesentericmicrocirculationuponexperimentalbyleishmaniasppinbalbcmice
_version_	1718407556724948992

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Ejemplares similares