Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

Fgf4 is a critical signal driving embryonic stem cell (ESC) exit from pluripotency and differentiation. Here the authors identify EPHA2 as a target of FGF4 signalling in ESCs, and show that EPHA2-EFNA1 signalling promotes pluripotent gene expression and suppresses commitment through repression of ER...

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Autores principales:	Rosalia Fernandez-Alonso, Francisco Bustos, Manon Budzyk, Pankaj Kumar, Andreas O. Helbig, Jens Hukelmann, Angus I. Lamond, Fredrik Lanner, Houjiang Zhou, Evangelia Petsalaki, Greg M. Findlay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df268364679f47c9817b1c300c169406
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spelling	oai:doaj.org-article:df268364679f47c9817b1c300c1694062021-12-02T15:37:21ZPhosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation10.1038/s41467-020-15173-42041-1723https://doaj.org/article/df268364679f47c9817b1c300c1694062020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15173-4https://doaj.org/toc/2041-1723Fgf4 is a critical signal driving embryonic stem cell (ESC) exit from pluripotency and differentiation. Here the authors identify EPHA2 as a target of FGF4 signalling in ESCs, and show that EPHA2-EFNA1 signalling promotes pluripotent gene expression and suppresses commitment through repression of ERK1/2 activation.Rosalia Fernandez-AlonsoFrancisco BustosManon BudzykPankaj KumarAndreas O. HelbigJens HukelmannAngus I. LamondFredrik LannerHoujiang ZhouEvangelia PetsalakiGreg M. FindlayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rosalia Fernandez-Alonso Francisco Bustos Manon Budzyk Pankaj Kumar Andreas O. Helbig Jens Hukelmann Angus I. Lamond Fredrik Lanner Houjiang Zhou Evangelia Petsalaki Greg M. Findlay Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
description	Fgf4 is a critical signal driving embryonic stem cell (ESC) exit from pluripotency and differentiation. Here the authors identify EPHA2 as a target of FGF4 signalling in ESCs, and show that EPHA2-EFNA1 signalling promotes pluripotent gene expression and suppresses commitment through repression of ERK1/2 activation.
format	article
author	Rosalia Fernandez-Alonso Francisco Bustos Manon Budzyk Pankaj Kumar Andreas O. Helbig Jens Hukelmann Angus I. Lamond Fredrik Lanner Houjiang Zhou Evangelia Petsalaki Greg M. Findlay
author_facet	Rosalia Fernandez-Alonso Francisco Bustos Manon Budzyk Pankaj Kumar Andreas O. Helbig Jens Hukelmann Angus I. Lamond Fredrik Lanner Houjiang Zhou Evangelia Petsalaki Greg M. Findlay
author_sort	Rosalia Fernandez-Alonso
title	Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
title_short	Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
title_full	Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
title_fullStr	Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
title_full_unstemmed	Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
title_sort	phosphoproteomics identifies a bimodal epha2 receptor switch that promotes embryonic stem cell differentiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/df268364679f47c9817b1c300c169406
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Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

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