Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.

The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and cognitive impairments. One hypothesis is that adult neurogenesis in the hippocampus enables spatial pattern separation, allowing animals to disti...

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Autores principales:	James O Groves, Isla Leslie, Guo-Jen Huang, Stephen B McHugh, Amy Taylor, Richard Mott, Marcus Munafò, David M Bannerman, Jonathan Flint
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/df29b10838c343d488cfe37549114dd1
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spelling	oai:doaj.org-article:df29b10838c343d488cfe37549114dd12021-11-18T06:21:56ZAblating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.1553-73901553-740410.1371/journal.pgen.1003718https://doaj.org/article/df29b10838c343d488cfe37549114dd12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039591/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and cognitive impairments. One hypothesis is that adult neurogenesis in the hippocampus enables spatial pattern separation, allowing animals to distinguish between similar stimuli. We investigated whether spatial pattern separation and other putative hippocampal functions of adult neurogenesis were altered in a novel genetic model of neurogenesis ablation in the rat. In rats engineered to express thymidine kinase (TK) from a promoter of the rat glial fibrillary acidic protein (GFAP), ganciclovir treatment reduced new neurons by 98%. GFAP-TK rats showed no significant difference from controls in spatial pattern separation on the radial maze, spatial learning in the water maze, contextual or cued fear conditioning. Meta-analysis of all published studies found no significant effects for ablation of adult neurogenesis on spatial memory, cue conditioning or ethological measures of anxiety. An effect on contextual freezing was significant at a threshold of 5% (P = 0.04), but not at a threshold corrected for multiple testing. The meta-analysis revealed remarkably high levels of heterogeneity among studies of hippocampal function. The source of this heterogeneity remains unclear and poses a challenge for studies of the function of adult neurogenesis.James O GrovesIsla LeslieGuo-Jen HuangStephen B McHughAmy TaylorRichard MottMarcus MunafòDavid M BannermanJonathan FlintPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 9, Iss 9, p e1003718 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 James O Groves Isla Leslie Guo-Jen Huang Stephen B McHugh Amy Taylor Richard Mott Marcus Munafò David M Bannerman Jonathan Flint Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
description	The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and cognitive impairments. One hypothesis is that adult neurogenesis in the hippocampus enables spatial pattern separation, allowing animals to distinguish between similar stimuli. We investigated whether spatial pattern separation and other putative hippocampal functions of adult neurogenesis were altered in a novel genetic model of neurogenesis ablation in the rat. In rats engineered to express thymidine kinase (TK) from a promoter of the rat glial fibrillary acidic protein (GFAP), ganciclovir treatment reduced new neurons by 98%. GFAP-TK rats showed no significant difference from controls in spatial pattern separation on the radial maze, spatial learning in the water maze, contextual or cued fear conditioning. Meta-analysis of all published studies found no significant effects for ablation of adult neurogenesis on spatial memory, cue conditioning or ethological measures of anxiety. An effect on contextual freezing was significant at a threshold of 5% (P = 0.04), but not at a threshold corrected for multiple testing. The meta-analysis revealed remarkably high levels of heterogeneity among studies of hippocampal function. The source of this heterogeneity remains unclear and poses a challenge for studies of the function of adult neurogenesis.
format	article
author	James O Groves Isla Leslie Guo-Jen Huang Stephen B McHugh Amy Taylor Richard Mott Marcus Munafò David M Bannerman Jonathan Flint
author_facet	James O Groves Isla Leslie Guo-Jen Huang Stephen B McHugh Amy Taylor Richard Mott Marcus Munafò David M Bannerman Jonathan Flint
author_sort	James O Groves
title	Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
title_short	Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
title_full	Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
title_fullStr	Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
title_full_unstemmed	Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
title_sort	ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/df29b10838c343d488cfe37549114dd1
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Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model.

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