The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma

The imbalance of high oxidative stress and low antioxidant capacities is thought to be a significant cause of the development and progression of hepatocellular carcinoma (HCC). However, the impact of oxidative stress, glutathione (GSH), and its related antioxidant enzymes on the recurrence of HCC ha...

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Autores principales:	Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glutathione glutathione peroxidase glutathione reductase oxidative stress hepatocellular carcinoma recurrence Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/df2ae57e01a842539effb32d05812ba4
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spelling	oai:doaj.org-article:df2ae57e01a842539effb32d05812ba42021-11-25T18:36:32ZThe Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma10.3390/nu131140712072-6643https://doaj.org/article/df2ae57e01a842539effb32d05812ba42021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4071https://doaj.org/toc/2072-6643The imbalance of high oxidative stress and low antioxidant capacities is thought to be a significant cause of the development and progression of hepatocellular carcinoma (HCC). However, the impact of oxidative stress, glutathione (GSH), and its related antioxidant enzymes on the recurrence of HCC has not been investigated. The purpose of this study was to compare the changes to oxidative stress and GSH-related antioxidant capacities before and after tumor resection in patients with HCC recurrence and non-recurrence. We also evaluated the prognostic significance of GSH and its related enzymes in HCC recurrence. This was a cross-sectional and follow-up study. Ninety-two HCC patients who were going to receive tumor resection were recruited. We followed patients’ recurrence and survival status until the end of the study, and then assigned patients into the recurrent or the non-recurrent group. The tumor recurrence rate was 52.2% during the median follow-up period of 3.0 years. Patients had significantly lower plasma malondialdehyde level, but significantly or slightly higher levels of GSH, glutathione disulfide, trolox equivalent antioxidant capacity, glutathione peroxidase (GPx), and glutathione reductase (GR) activities after tumor resection compared to the respective levels before tumor resection in both recurrent and non-recurrent groups. GSH level in HCC tissue was significantly higher than that in adjacent normal tissue in both recurrent and non-recurrent patients. Decreased plasma GPx (HR = 0.995, <i>p</i> = 0.01) and GR (HR = 0.98, <i>p</i> = 0.04) activities before tumor resection, and the increased change of GPx (post—pre-resection) (HR = 1.004, <i>p</i> = 0.03) activity were significantly associated with the recurrence of HCC. These findings suggest there might be a possible application of GPx or GR as therapeutic targets for reducing HCC recurrence.Yung-Fang HsiaoShao-Bin ChengChia-Yu LaiHsiao-Tien LiuShih-Chien HuangYi-Chia HuangMDPI AGarticleglutathioneglutathione peroxidaseglutathione reductaseoxidative stresshepatocellular carcinomarecurrenceNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4071, p 4071 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glutathione glutathione peroxidase glutathione reductase oxidative stress hepatocellular carcinoma recurrence Nutrition. Foods and food supply TX341-641
spellingShingle	glutathione glutathione peroxidase glutathione reductase oxidative stress hepatocellular carcinoma recurrence Nutrition. Foods and food supply TX341-641 Yung-Fang Hsiao Shao-Bin Cheng Chia-Yu Lai Hsiao-Tien Liu Shih-Chien Huang Yi-Chia Huang The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
description	The imbalance of high oxidative stress and low antioxidant capacities is thought to be a significant cause of the development and progression of hepatocellular carcinoma (HCC). However, the impact of oxidative stress, glutathione (GSH), and its related antioxidant enzymes on the recurrence of HCC has not been investigated. The purpose of this study was to compare the changes to oxidative stress and GSH-related antioxidant capacities before and after tumor resection in patients with HCC recurrence and non-recurrence. We also evaluated the prognostic significance of GSH and its related enzymes in HCC recurrence. This was a cross-sectional and follow-up study. Ninety-two HCC patients who were going to receive tumor resection were recruited. We followed patients’ recurrence and survival status until the end of the study, and then assigned patients into the recurrent or the non-recurrent group. The tumor recurrence rate was 52.2% during the median follow-up period of 3.0 years. Patients had significantly lower plasma malondialdehyde level, but significantly or slightly higher levels of GSH, glutathione disulfide, trolox equivalent antioxidant capacity, glutathione peroxidase (GPx), and glutathione reductase (GR) activities after tumor resection compared to the respective levels before tumor resection in both recurrent and non-recurrent groups. GSH level in HCC tissue was significantly higher than that in adjacent normal tissue in both recurrent and non-recurrent patients. Decreased plasma GPx (HR = 0.995, <i>p</i> = 0.01) and GR (HR = 0.98, <i>p</i> = 0.04) activities before tumor resection, and the increased change of GPx (post—pre-resection) (HR = 1.004, <i>p</i> = 0.03) activity were significantly associated with the recurrence of HCC. These findings suggest there might be a possible application of GPx or GR as therapeutic targets for reducing HCC recurrence.
format	article
author	Yung-Fang Hsiao Shao-Bin Cheng Chia-Yu Lai Hsiao-Tien Liu Shih-Chien Huang Yi-Chia Huang
author_facet	Yung-Fang Hsiao Shao-Bin Cheng Chia-Yu Lai Hsiao-Tien Liu Shih-Chien Huang Yi-Chia Huang
author_sort	Yung-Fang Hsiao
title	The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
title_short	The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
title_full	The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
title_fullStr	The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
title_full_unstemmed	The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma
title_sort	prognostic role of glutathione and its related antioxidant enzymes in the recurrence of hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/df2ae57e01a842539effb32d05812ba4
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The Prognostic Role of Glutathione and Its Related Antioxidant Enzymes in the Recurrence of Hepatocellular Carcinoma

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