A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context...

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Autores principales:	Rebecca A. Dagg, Gijs Zonderland, Emilia Puig Lombardi, Giacomo G. Rossetti, Florian J. Groelly, Sonia Barroso, Eliana M. C. Tacconi, Benjamin Wright, Helen Lockstone, Andrés Aguilera, Thanos D. Halazonetis, Madalena Tarsounas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec
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spelling	oai:doaj.org-article:df2c21948aa4474d8a16c5c108679eec2021-12-02T19:06:43ZA transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells10.1038/s41467-021-25215-02041-1723https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25215-0https://doaj.org/toc/2041-1723Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency.Rebecca A. DaggGijs ZonderlandEmilia Puig LombardiGiacomo G. RossettiFlorian J. GroellySonia BarrosoEliana M. C. TacconiBenjamin WrightHelen LockstoneAndrés AguileraThanos D. HalazonetisMadalena TarsounasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
description	Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency.
format	article
author	Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas
author_facet	Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas
author_sort	Rebecca A. Dagg
title	A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
title_short	A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
title_full	A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
title_fullStr	A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
title_full_unstemmed	A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
title_sort	transcription-based mechanism for oncogenic β-catenin-induced lethality in brca1/2-deficient cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec
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A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

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