Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin

The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveol...

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Autores principales:	Zoran Lazić, Marija Bubalo, Radomir Milović, Stevo Matijević, Marko Magić, Igor Đorđević
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	bovine resorbable membrane dog mandible defect guided bone regeneration human resorbable membrane membrane thickness Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/df2e30fd4f104759b85820913ef2f618
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spelling	oai:doaj.org-article:df2e30fd4f104759b85820913ef2f6182021-11-17T21:27:52ZComparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin1820-744810.2478/acve-2014-0045https://doaj.org/article/df2e30fd4f104759b85820913ef2f6182014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0045https://doaj.org/toc/1820-7448The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the fl ap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the infl uence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one.Zoran LazićMarija BubaloRadomir MilovićStevo MatijevićMarko MagićIgor ĐorđevićSciendoarticlebovine resorbable membranedog mandible defectguided bone regenerationhuman resorbable membranemembrane thicknessVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 477-492 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	bovine resorbable membrane dog mandible defect guided bone regeneration human resorbable membrane membrane thickness Veterinary medicine SF600-1100
spellingShingle	bovine resorbable membrane dog mandible defect guided bone regeneration human resorbable membrane membrane thickness Veterinary medicine SF600-1100 Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
description	The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the fl ap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the infl uence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one.
format	article
author	Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević
author_facet	Zoran Lazić Marija Bubalo Radomir Milović Stevo Matijević Marko Magić Igor Đorđević
author_sort	Zoran Lazić
title	Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
title_short	Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
title_full	Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
title_fullStr	Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
title_full_unstemmed	Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin
title_sort	comparison of resorbable membranes for guided bone regeneration of human and bovine origin
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/df2e30fd4f104759b85820913ef2f618
work_keys_str_mv	AT zoranlazic comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin AT marijabubalo comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin AT radomirmilovic comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin AT stevomatijevic comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin AT markomagic comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin AT igorđorđevic comparisonofresorbablemembranesforguidedboneregenerationofhumanandbovineorigin
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Comparison of Resorbable Membranes for Guided Bone Regeneration of Human and Bovine Origin

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