MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung

MicroRNAs (miRNAs) have become a major object of investigation in the recent years. These small non-coding RNAs regulate gene expression at the post-transcriptional level and there is growing evidence that they are involved in a plethora of biological processes. With exercise as a potent trigger for...

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Autores principales:	Meurer S, Krüger K, Mooren FC
Formato:	article
Lenguaje:	DE EN
Publicado:	Dynamic Media Sales Verlag 2016
Materias:	Sports medicine RC1200-1245
Acceso en línea:	https://doaj.org/article/df2f7257088a4e2a8117064794068871
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spelling	oai:doaj.org-article:df2f7257088a4e2a81170647940688712021-11-16T19:01:42ZMicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung0344-59252510-526410.5960/dzsm.2015.205https://doaj.org/article/df2f7257088a4e2a81170647940688712016-02-01T00:00:00Zhttps://www.germanjournalsportsmedicine.com/archive/archive-2016/issue-2/micrornas-and-exercise/https://doaj.org/toc/0344-5925https://doaj.org/toc/2510-5264MicroRNAs (miRNAs) have become a major object of investigation in the recent years. These small non-coding RNAs regulate gene expression at the post-transcriptional level and there is growing evidence that they are involved in a plethora of biological processes. With exercise as a potent trigger for adaptational responses thataffectvirtually all systems of the body, understanding miRNAs is a precondition for deeper insight into the adaptation of skeletal muscle (i.e. growth/regeneration) following exercise. These adaptations involve an increased need of protein synthesis regarding both resistance exercise and chronic endurance exercise. Apart from protein synthesis,miRNAs have a meaningful impact on regulating metabolic changes (e.g. muscle fiber phenotype/mitochondrial bio-genesis) as well. Altogether, these responses might be necessary to facilitate adaptation and regeneration following exercise.The role of miRNAs in circulation (c-miRNAs) has gathered considerable attention in recent years. It is of great interestwhether and how c-miRNAs modulated by exercise play a role in cell-to-cell communication and might be further considered responsible for beneficial effects in peripheral organs.This review summarizes what is currently known about the impact of miRNAs in skeletal muscle and their potential role as circulating biomarkers in response to either acute and/or chronic exercise with various modalities.KEY WORDS: MicroRNA, Exercise, Circulating MicroRNAs,&nbsp;Skeletal Muscle, Cardiovascular SystemMeurer SKrüger KMooren FCDynamic Media Sales VerlagarticleSports medicineRC1200-1245DEENDeutsche Zeitschrift für Sportmedizin, Vol 67, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	DE EN
topic	Sports medicine RC1200-1245
spellingShingle	Sports medicine RC1200-1245 Meurer S Krüger K Mooren FC MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
description	MicroRNAs (miRNAs) have become a major object of investigation in the recent years. These small non-coding RNAs regulate gene expression at the post-transcriptional level and there is growing evidence that they are involved in a plethora of biological processes. With exercise as a potent trigger for adaptational responses thataffectvirtually all systems of the body, understanding miRNAs is a precondition for deeper insight into the adaptation of skeletal muscle (i.e. growth/regeneration) following exercise. These adaptations involve an increased need of protein synthesis regarding both resistance exercise and chronic endurance exercise. Apart from protein synthesis,miRNAs have a meaningful impact on regulating metabolic changes (e.g. muscle fiber phenotype/mitochondrial bio-genesis) as well. Altogether, these responses might be necessary to facilitate adaptation and regeneration following exercise.The role of miRNAs in circulation (c-miRNAs) has gathered considerable attention in recent years. It is of great interestwhether and how c-miRNAs modulated by exercise play a role in cell-to-cell communication and might be further considered responsible for beneficial effects in peripheral organs.This review summarizes what is currently known about the impact of miRNAs in skeletal muscle and their potential role as circulating biomarkers in response to either acute and/or chronic exercise with various modalities.KEY WORDS: MicroRNA, Exercise, Circulating MicroRNAs,&nbsp;Skeletal Muscle, Cardiovascular System
format	article
author	Meurer S Krüger K Mooren FC
author_facet	Meurer S Krüger K Mooren FC
author_sort	Meurer S
title	MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
title_short	MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
title_full	MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
title_fullStr	MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
title_full_unstemmed	MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung
title_sort	micrornas and exercise / micrornas unter einfluss körperlicher belastung
publisher	Dynamic Media Sales Verlag
publishDate	2016
url	https://doaj.org/article/df2f7257088a4e2a8117064794068871
work_keys_str_mv	AT meurers micrornasandexercisemicrornasuntereinflusskorperlicherbelastung AT krugerk micrornasandexercisemicrornasuntereinflusskorperlicherbelastung AT moorenfc micrornasandexercisemicrornasuntereinflusskorperlicherbelastung
_version_	1718426208740311040

MicroRNAs and Exercise / MicroRNAs unter Einfluss körperlicher Belastung

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