Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection

Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuqi Peng, Gan Lin, Yun Zeng, Zhao Lei, Gang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mesoporous silica nanoparticles hepatocellular carcinoma diagnostics multimodal imaging biomedical applications Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/df306c76fa774e0490629dce0c96249b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df306c76fa774e0490629dce0c96249b
record_format	dspace
spelling	oai:doaj.org-article:df306c76fa774e0490629dce0c96249b2021-11-16T07:26:28ZMesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection2296-418510.3389/fbioe.2021.749381https://doaj.org/article/df306c76fa774e0490629dce0c96249b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.749381/fullhttps://doaj.org/toc/2296-4185Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effective imaging agents with superior diagnostic precision for HCC detection at an early stage. Recently, mesoporous silica nanoparticles (MSNs) based imaging agents have gained extensive attentions in HCC detection, which can serve as a multifunctional nanoplatform with controllable size and facile surface functionalization. This perspective summarizes recent advances in MSNs based imaging agents for HCC detection by the incorporation of several clinical imaging modalities. Multi-modal imaging system has been developed for higher spatial resolution and sensitivity. Even though some limitations and challenges need to be overcome, we envision the development of novel MSNs based imaging agents will offer great potential applications in clinical HCC detection.Xuqi PengGan LinYun ZengZhao LeiGang LiuFrontiers Media S.A.articlemesoporous silica nanoparticleshepatocellular carcinomadiagnosticsmultimodal imagingbiomedical applicationsBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica nanoparticles hepatocellular carcinoma diagnostics multimodal imaging biomedical applications Biotechnology TP248.13-248.65
spellingShingle	mesoporous silica nanoparticles hepatocellular carcinoma diagnostics multimodal imaging biomedical applications Biotechnology TP248.13-248.65 Xuqi Peng Gan Lin Yun Zeng Zhao Lei Gang Liu Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
description	Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effective imaging agents with superior diagnostic precision for HCC detection at an early stage. Recently, mesoporous silica nanoparticles (MSNs) based imaging agents have gained extensive attentions in HCC detection, which can serve as a multifunctional nanoplatform with controllable size and facile surface functionalization. This perspective summarizes recent advances in MSNs based imaging agents for HCC detection by the incorporation of several clinical imaging modalities. Multi-modal imaging system has been developed for higher spatial resolution and sensitivity. Even though some limitations and challenges need to be overcome, we envision the development of novel MSNs based imaging agents will offer great potential applications in clinical HCC detection.
format	article
author	Xuqi Peng Gan Lin Yun Zeng Zhao Lei Gang Liu
author_facet	Xuqi Peng Gan Lin Yun Zeng Zhao Lei Gang Liu
author_sort	Xuqi Peng
title	Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_short	Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_full	Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_fullStr	Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_full_unstemmed	Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_sort	mesoporous silica nanoparticle-based imaging agents for hepatocellular carcinoma detection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/df306c76fa774e0490629dce0c96249b
work_keys_str_mv	AT xuqipeng mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection AT ganlin mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection AT yunzeng mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection AT zhaolei mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection AT gangliu mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection
_version_	1718426637051101184

Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection

Ejemplares similares