Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting...

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Autores principales: Biao Ma, Hongcheng Cheng, Ruize Gao, Chenglong Mu, Ling Chen, Shian Wu, Quan Chen, Yushan Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/df320a3c123e49cb9592da2d8a71e6c8
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Sumario:Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting Lats2 degradation and YAP activation.