Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting...

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Autores principales: Biao Ma, Hongcheng Cheng, Ruize Gao, Chenglong Mu, Ling Chen, Shian Wu, Quan Chen, Yushan Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/df320a3c123e49cb9592da2d8a71e6c8
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spelling oai:doaj.org-article:df320a3c123e49cb9592da2d8a71e6c82021-12-02T15:34:50ZZyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways10.1038/ncomms111232041-1723https://doaj.org/article/df320a3c123e49cb9592da2d8a71e6c82016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11123https://doaj.org/toc/2041-1723Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting Lats2 degradation and YAP activation.Biao MaHongcheng ChengRuize GaoChenglong MuLing ChenShian WuQuan ChenYushan ZhuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Biao Ma
Hongcheng Cheng
Ruize Gao
Chenglong Mu
Ling Chen
Shian Wu
Quan Chen
Yushan Zhu
Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
description Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting Lats2 degradation and YAP activation.
format article
author Biao Ma
Hongcheng Cheng
Ruize Gao
Chenglong Mu
Ling Chen
Shian Wu
Quan Chen
Yushan Zhu
author_facet Biao Ma
Hongcheng Cheng
Ruize Gao
Chenglong Mu
Ling Chen
Shian Wu
Quan Chen
Yushan Zhu
author_sort Biao Ma
title Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
title_short Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
title_full Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
title_fullStr Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
title_full_unstemmed Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
title_sort zyxin-siah2–lats2 axis mediates cooperation between hippo and tgf-β signalling pathways
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/df320a3c123e49cb9592da2d8a71e6c8
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