A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy

Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that...

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Autores principales:	Re-I Chin, Joshua P. Schiff, Randall J. Brenneman, Hiram A. Gay, Wade L. Thorstad, Alexander J. Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radiation therapy head and neck cancer immunotherapy unilateral neck RT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/df324d6107dc4b3ba9dfbe648f441e7e
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spelling	oai:doaj.org-article:df324d6107dc4b3ba9dfbe648f441e7e2021-11-11T15:26:44ZA Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy10.3390/cancers132152692072-6694https://doaj.org/article/df324d6107dc4b3ba9dfbe648f441e7e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5269https://doaj.org/toc/2072-6694Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.Re-I ChinJoshua P. SchiffRandall J. BrennemanHiram A. GayWade L. ThorstadAlexander J. LinMDPI AGarticleradiation therapyhead and neck cancerimmunotherapyunilateral neck RTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5269, p 5269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiation therapy head and neck cancer immunotherapy unilateral neck RT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiation therapy head and neck cancer immunotherapy unilateral neck RT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Re-I Chin Joshua P. Schiff Randall J. Brenneman Hiram A. Gay Wade L. Thorstad Alexander J. Lin A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
description	Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.
format	article
author	Re-I Chin Joshua P. Schiff Randall J. Brenneman Hiram A. Gay Wade L. Thorstad Alexander J. Lin
author_facet	Re-I Chin Joshua P. Schiff Randall J. Brenneman Hiram A. Gay Wade L. Thorstad Alexander J. Lin
author_sort	Re-I Chin
title	A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
title_short	A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
title_full	A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
title_fullStr	A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
title_full_unstemmed	A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy
title_sort	rational approach to unilateral neck rt for head and neck cancers in the era of immunotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/df324d6107dc4b3ba9dfbe648f441e7e
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A Rational Approach to Unilateral Neck RT for Head and Neck Cancers in the Era of Immunotherapy

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