Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress

The autophagy receptor p62 mediates the assembly and removal of ubiquitylated protein aggregates by forming p62 bodies. Here, the authors identify an acetylation-dependent mechanism that regulates formation and autophagic clearance of p62 bodies under nutrient-deficient conditions.

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Autores principales: Zhiyuan You, Wen-Xue Jiang, Ling-Yun Qin, Zhou Gong, Wei Wan, Jin Li, Yusha Wang, Hongtao Zhang, Chao Peng, Tianhua Zhou, Chun Tang, Wei Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/df3739c6d5be4f2fb8d8248924f5b8fd
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