Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer c...

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Autores principales:	Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C. Dean, Miriam Cuatrecasas, Antonio Postigo, Douglas C. Dean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df38bfb58c814b399b684abd35f65259
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spelling	oai:doaj.org-article:df38bfb58c814b399b684abd35f652592021-12-02T16:49:35ZMitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells10.1038/s41467-018-04663-12041-1723https://doaj.org/article/df38bfb58c814b399b684abd35f652592018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04663-1https://doaj.org/toc/2041-1723Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer cells.Yongqing LiuLaura SilesXiaoqin LuKevin C. DeanMiriam CuatrecasasAntonio PostigoDouglas C. DeanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongqing Liu Laura Siles Xiaoqin Lu Kevin C. Dean Miriam Cuatrecasas Antonio Postigo Douglas C. Dean Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
description	Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer cells.
format	article
author	Yongqing Liu Laura Siles Xiaoqin Lu Kevin C. Dean Miriam Cuatrecasas Antonio Postigo Douglas C. Dean
author_facet	Yongqing Liu Laura Siles Xiaoqin Lu Kevin C. Dean Miriam Cuatrecasas Antonio Postigo Douglas C. Dean
author_sort	Yongqing Liu
title	Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_short	Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_full	Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_fullStr	Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_full_unstemmed	Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_sort	mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df38bfb58c814b399b684abd35f65259
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Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

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