Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

Abstract Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemic...

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Autores principales:	Paul Christian, Stephan Tumphart, Heike M. A. Ehmann, Hans Riegler, Anna Maria Coclite, Oliver Werzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df3a2d6c32f34d6f95048a1f90cf3a8d
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spelling	oai:doaj.org-article:df3a2d6c32f34d6f95048a1f90cf3a8d2021-12-02T15:05:30ZControlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density10.1038/s41598-018-24238-w2045-2322https://doaj.org/article/df3a2d6c32f34d6f95048a1f90cf3a8d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24238-whttps://doaj.org/toc/2045-2322Abstract Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.Paul ChristianStephan TumphartHeike M. A. EhmannHans RieglerAnna Maria CocliteOliver WerzerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul Christian Stephan Tumphart Heike M. A. Ehmann Hans Riegler Anna Maria Coclite Oliver Werzer Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
description	Abstract Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.
format	article
author	Paul Christian Stephan Tumphart Heike M. A. Ehmann Hans Riegler Anna Maria Coclite Oliver Werzer
author_facet	Paul Christian Stephan Tumphart Heike M. A. Ehmann Hans Riegler Anna Maria Coclite Oliver Werzer
author_sort	Paul Christian
title	Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
title_short	Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
title_full	Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
title_fullStr	Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
title_full_unstemmed	Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density
title_sort	controlling indomethacin release through vapor-phase deposited hydrogel films by adjusting the cross-linker density
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df3a2d6c32f34d6f95048a1f90cf3a8d
work_keys_str_mv	AT paulchristian controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity AT stephantumphart controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity AT heikemaehmann controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity AT hansriegler controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity AT annamariacoclite controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity AT oliverwerzer controllingindomethacinreleasethroughvaporphasedepositedhydrogelfilmsbyadjustingthecrosslinkerdensity
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Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

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