AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Abstract. The levels of autoantibodies to collagen type I, II, III, IV and V were studied in blood plasma of 130 patients (18-32 years old) with undifferentiated connective tissue dysplasia, using immunoenzyme analysis. A correlation was revealed between the levels of autoantibodies to various colla...

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Autores principales:	A. V. Yagoda, N. N. Gladkikh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoantibodies collagen connective tissue dysplasia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/df3da66efcd0424fac33f30dc033873c
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spelling	oai:doaj.org-article:df3da66efcd0424fac33f30dc033873c2021-11-18T08:03:38ZAUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA1563-06252313-741X10.15789/1563-0625-2007-1-61-68https://doaj.org/article/df3da66efcd0424fac33f30dc033873c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/126https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The levels of autoantibodies to collagen type I, II, III, IV and V were studied in blood plasma of 130 patients (18-32 years old) with undifferentiated connective tissue dysplasia, using immunoenzyme analysis. A correlation was revealed between the levels of autoantibodies to various collagen types, and external and/or heart manifestations of connective tissue dysplasia. Increased levels of autoantibodies to collagen type I and II were shown in patients with chest deformation, scoliosis, pronounced joint hypermobility syndrome, multiple minor intracardial anomalies. Increased antibodies to type I collagen were associated with flat-footedness, whereas levels of antibodies to collagen type I, II, and V correlated with myxomatous degeneration of mitral valve prolapse. Increase in anticollagen antibody levels in cases of pronounced external and cardiac markers of connective tissue dysplasia suggests an impairment of autoimmune regulatory mechanisms of collagen metabolism.A. V. YagodaN. N. GladkikhSPb RAACIarticleautoantibodiescollagenconnective tissue dysplasiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 1, Pp 61-68 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies collagen connective tissue dysplasia Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies collagen connective tissue dysplasia Immunologic diseases. Allergy RC581-607 A. V. Yagoda N. N. Gladkikh AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
description	Abstract. The levels of autoantibodies to collagen type I, II, III, IV and V were studied in blood plasma of 130 patients (18-32 years old) with undifferentiated connective tissue dysplasia, using immunoenzyme analysis. A correlation was revealed between the levels of autoantibodies to various collagen types, and external and/or heart manifestations of connective tissue dysplasia. Increased levels of autoantibodies to collagen type I and II were shown in patients with chest deformation, scoliosis, pronounced joint hypermobility syndrome, multiple minor intracardial anomalies. Increased antibodies to type I collagen were associated with flat-footedness, whereas levels of antibodies to collagen type I, II, and V correlated with myxomatous degeneration of mitral valve prolapse. Increase in anticollagen antibody levels in cases of pronounced external and cardiac markers of connective tissue dysplasia suggests an impairment of autoimmune regulatory mechanisms of collagen metabolism.
format	article
author	A. V. Yagoda N. N. Gladkikh
author_facet	A. V. Yagoda N. N. Gladkikh
author_sort	A. V. Yagoda
title	AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
title_short	AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
title_full	AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
title_fullStr	AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
title_full_unstemmed	AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
title_sort	autoimmune aspects of collagen homeostasis disorder in undifferentiated connective tissue dysplasia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/df3da66efcd0424fac33f30dc033873c
work_keys_str_mv	AT avyagoda autoimmuneaspectsofcollagenhomeostasisdisorderinundifferentiatedconnectivetissuedysplasia AT nngladkikh autoimmuneaspectsofcollagenhomeostasisdisorderinundifferentiatedconnectivetissuedysplasia
_version_	1718422574598193152

AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

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