A high-glucose diet affects Achilles tendon healing in rats
Abstract Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positi...
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Nature Portfolio
2017
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oai:doaj.org-article:df41000099164f44a7877e36f5e7efa52021-12-02T12:31:55ZA high-glucose diet affects Achilles tendon healing in rats10.1038/s41598-017-00700-z2045-2322https://doaj.org/article/df41000099164f44a7877e36f5e7efa52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00700-zhttps://doaj.org/toc/2045-2322Abstract Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively. Compared to the control group, tendon repair tissue thickness and stiffness were increased in the high-glucose group after 2 weeks and gait pattern was altered after 1 and 2 weeks. Cell proliferation was up to 3-fold higher and the expression of the chondrogenic marker genes Sox9, Col2a1, Acan and Comp was significantly increased 2 and 4 weeks post-surgery. Further, a moderate increase in cartilage-like areas within the repair tissue was evident after 4 weeks of a high-glucose diet regimen. In summary, we propose that a high-glucose diet significantly affects tendon healing after injury in non-diabetic rats, potentially driving chondrogenic degeneration.Stefanie KorntnerNadja KunkelChristine LehnerRenate GehwolfAndrea WagnerPeter AugatDaniel StephanVerena HeuHans-Christian BauerAndreas TrawegerHerbert TempferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
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Medicine R Science Q Stefanie Korntner Nadja Kunkel Christine Lehner Renate Gehwolf Andrea Wagner Peter Augat Daniel Stephan Verena Heu Hans-Christian Bauer Andreas Traweger Herbert Tempfer A high-glucose diet affects Achilles tendon healing in rats |
| description |
Abstract Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively. Compared to the control group, tendon repair tissue thickness and stiffness were increased in the high-glucose group after 2 weeks and gait pattern was altered after 1 and 2 weeks. Cell proliferation was up to 3-fold higher and the expression of the chondrogenic marker genes Sox9, Col2a1, Acan and Comp was significantly increased 2 and 4 weeks post-surgery. Further, a moderate increase in cartilage-like areas within the repair tissue was evident after 4 weeks of a high-glucose diet regimen. In summary, we propose that a high-glucose diet significantly affects tendon healing after injury in non-diabetic rats, potentially driving chondrogenic degeneration. |
| format |
article |
| author |
Stefanie Korntner Nadja Kunkel Christine Lehner Renate Gehwolf Andrea Wagner Peter Augat Daniel Stephan Verena Heu Hans-Christian Bauer Andreas Traweger Herbert Tempfer |
| author_facet |
Stefanie Korntner Nadja Kunkel Christine Lehner Renate Gehwolf Andrea Wagner Peter Augat Daniel Stephan Verena Heu Hans-Christian Bauer Andreas Traweger Herbert Tempfer |
| author_sort |
Stefanie Korntner |
| title |
A high-glucose diet affects Achilles tendon healing in rats |
| title_short |
A high-glucose diet affects Achilles tendon healing in rats |
| title_full |
A high-glucose diet affects Achilles tendon healing in rats |
| title_fullStr |
A high-glucose diet affects Achilles tendon healing in rats |
| title_full_unstemmed |
A high-glucose diet affects Achilles tendon healing in rats |
| title_sort |
high-glucose diet affects achilles tendon healing in rats |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/df41000099164f44a7877e36f5e7efa5 |
| work_keys_str_mv |
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