Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation

Although histamine is a well-known itch mediator, histamine H<sub>1</sub>-receptor blockers often lack efficacy in chronic itch. Recent molecular and cellular based studies have shown that non-histaminergic mediators, such as proteases, neuropeptides and cytokines, along with their cogna...

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Main Authors:	Sumika Toyama, Mitsutoshi Tominaga, Kenji Takamori
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	cytokines immune cell itch mediator and modulator sensory neuron Biology (General) QH301-705.5 Chemistry QD1-999
Online Access:	https://doaj.org/article/df42df9e15f34e7594ca44fe8b8e5149
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spelling	oai:doaj.org-article:df42df9e15f34e7594ca44fe8b8e51492021-11-25T17:55:44ZConnections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation10.3390/ijms2222123651422-00671661-6596https://doaj.org/article/df42df9e15f34e7594ca44fe8b8e51492021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12365https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Although histamine is a well-known itch mediator, histamine H<sub>1</sub>-receptor blockers often lack efficacy in chronic itch. Recent molecular and cellular based studies have shown that non-histaminergic mediators, such as proteases, neuropeptides and cytokines, along with their cognate receptors, are involved in evocation and modulation of itch sensation. Many of these molecules are produced and secreted by immune cells, which act on sensory nerve fibers distributed in the skin to cause itching and sensitization. This understanding of the connections between immune cell-derived mediators and sensory nerve fibers has led to the development of new treatments for itch. This review summarizes current knowledge of immune cell-derived itch mediators and neuronal response mechanisms, and discusses therapeutic agents that target these systems.Sumika ToyamaMitsutoshi TominagaKenji TakamoriMDPI AGarticlecytokinesimmune cellitch mediator and modulatorsensory neuronBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12365, p 12365 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokines immune cell itch mediator and modulator sensory neuron Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cytokines immune cell itch mediator and modulator sensory neuron Biology (General) QH301-705.5 Chemistry QD1-999 Sumika Toyama Mitsutoshi Tominaga Kenji Takamori Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
description	Although histamine is a well-known itch mediator, histamine H<sub>1</sub>-receptor blockers often lack efficacy in chronic itch. Recent molecular and cellular based studies have shown that non-histaminergic mediators, such as proteases, neuropeptides and cytokines, along with their cognate receptors, are involved in evocation and modulation of itch sensation. Many of these molecules are produced and secreted by immune cells, which act on sensory nerve fibers distributed in the skin to cause itching and sensitization. This understanding of the connections between immune cell-derived mediators and sensory nerve fibers has led to the development of new treatments for itch. This review summarizes current knowledge of immune cell-derived itch mediators and neuronal response mechanisms, and discusses therapeutic agents that target these systems.
format	article
author	Sumika Toyama Mitsutoshi Tominaga Kenji Takamori
author_facet	Sumika Toyama Mitsutoshi Tominaga Kenji Takamori
author_sort	Sumika Toyama
title	Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
title_short	Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
title_full	Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
title_fullStr	Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
title_full_unstemmed	Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation
title_sort	connections between immune-derived mediators and sensory nerves for itch sensation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/df42df9e15f34e7594ca44fe8b8e5149
work_keys_str_mv	AT sumikatoyama connectionsbetweenimmunederivedmediatorsandsensorynervesforitchsensation AT mitsutoshitominaga connectionsbetweenimmunederivedmediatorsandsensorynervesforitchsensation AT kenjitakamori connectionsbetweenimmunederivedmediatorsandsensorynervesforitchsensation
_version_	1718411836087336960

Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation

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