Quantitative structural mechanobiology of platelet-driven blood clot contraction

Blood clot contraction is a cellular (patho)physiological process essential for wound healing, hemostasis, and thrombosis. Here, the authors describe the physical structural mechanism by which platelet filopodia pull “hand-over-hand” on fibrin fibers to compact them into bundled agglomerates.

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Detalles Bibliográficos
Autores principales: Oleg V. Kim, Rustem I. Litvinov, Mark S. Alber, John W. Weisel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/df430f98264444b08d73fd6114ec0f83
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Descripción
Sumario:Blood clot contraction is a cellular (patho)physiological process essential for wound healing, hemostasis, and thrombosis. Here, the authors describe the physical structural mechanism by which platelet filopodia pull “hand-over-hand” on fibrin fibers to compact them into bundled agglomerates.