CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

CTCF is as an architectural protein involved in 3D genome folding; however its contribution to animal development has not been well characterized. Here the authors show that CTCF is not only pivotal for 3D chromatin structure and enhancer-promoter interactions in zebrafish, but it is also essential...

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Autores principales:	Martin Franke, Elisa De la Calle-Mustienes, Ana Neto, María Almuedo-Castillo, Ibai Irastorza-Azcarate, Rafael D. Acemel, Juan J. Tena, José M. Santos-Pereira, José L. Gómez-Skarmeta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df452f901a8b424b89ef96928d45625f
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spelling	oai:doaj.org-article:df452f901a8b424b89ef96928d45625f2021-12-02T17:25:34ZCTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression10.1038/s41467-021-25604-52041-1723https://doaj.org/article/df452f901a8b424b89ef96928d45625f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25604-5https://doaj.org/toc/2041-1723CTCF is as an architectural protein involved in 3D genome folding; however its contribution to animal development has not been well characterized. Here the authors show that CTCF is not only pivotal for 3D chromatin structure and enhancer-promoter interactions in zebrafish, but it is also essential for controlling the expression of thousands of genes during development.Martin FrankeElisa De la Calle-MustienesAna NetoMaría Almuedo-CastilloIbai Irastorza-AzcarateRafael D. AcemelJuan J. TenaJosé M. Santos-PereiraJosé L. Gómez-SkarmetaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Franke Elisa De la Calle-Mustienes Ana Neto María Almuedo-Castillo Ibai Irastorza-Azcarate Rafael D. Acemel Juan J. Tena José M. Santos-Pereira José L. Gómez-Skarmeta CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
description	CTCF is as an architectural protein involved in 3D genome folding; however its contribution to animal development has not been well characterized. Here the authors show that CTCF is not only pivotal for 3D chromatin structure and enhancer-promoter interactions in zebrafish, but it is also essential for controlling the expression of thousands of genes during development.
format	article
author	Martin Franke Elisa De la Calle-Mustienes Ana Neto María Almuedo-Castillo Ibai Irastorza-Azcarate Rafael D. Acemel Juan J. Tena José M. Santos-Pereira José L. Gómez-Skarmeta
author_facet	Martin Franke Elisa De la Calle-Mustienes Ana Neto María Almuedo-Castillo Ibai Irastorza-Azcarate Rafael D. Acemel Juan J. Tena José M. Santos-Pereira José L. Gómez-Skarmeta
author_sort	Martin Franke
title	CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
title_short	CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
title_full	CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
title_fullStr	CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
title_full_unstemmed	CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
title_sort	ctcf knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df452f901a8b424b89ef96928d45625f
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CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

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