Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer

Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.

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Autores principales:	Jingying Nong, Yuhua Gong, Yanfang Guan, Xin Yi, Yuting Yi, Lianpeng Chang, Ling Yang, Jialin Lv, Zhirong Guo, Hongyan Jia, Yuxing Chu, Tao Liu, Ming Chen, Lauren Byers, Emily Roarty, Vincent K. Lam, Vassiliki A. Papadimitrakopoulou, Ignacio Wistuba, John V. Heymach, Bonnie Glisson, Zhongxing Liao, J. Jack Lee, P. Andrew Futreal, Shucai Zhang, Xuefeng Xia, Jianjun Zhang, Jinghui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df46aaa96e964fb0b1ab355342fd71b1
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spelling	oai:doaj.org-article:df46aaa96e964fb0b1ab355342fd71b12021-12-02T16:56:57ZCirculating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer10.1038/s41467-018-05327-w2041-1723https://doaj.org/article/df46aaa96e964fb0b1ab355342fd71b12018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05327-whttps://doaj.org/toc/2041-1723Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.Jingying NongYuhua GongYanfang GuanXin YiYuting YiLianpeng ChangLing YangJialin LvZhirong GuoHongyan JiaYuxing ChuTao LiuMing ChenLauren ByersEmily RoartyVincent K. LamVassiliki A. PapadimitrakopoulouIgnacio WistubaJohn V. HeymachBonnie GlissonZhongxing LiaoJ. Jack LeeP. Andrew FutrealShucai ZhangXuefeng XiaJianjun ZhangJinghui WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingying Nong Yuhua Gong Yanfang Guan Xin Yi Yuting Yi Lianpeng Chang Ling Yang Jialin Lv Zhirong Guo Hongyan Jia Yuxing Chu Tao Liu Ming Chen Lauren Byers Emily Roarty Vincent K. Lam Vassiliki A. Papadimitrakopoulou Ignacio Wistuba John V. Heymach Bonnie Glisson Zhongxing Liao J. Jack Lee P. Andrew Futreal Shucai Zhang Xuefeng Xia Jianjun Zhang Jinghui Wang Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
description	Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.
format	article
author	Jingying Nong Yuhua Gong Yanfang Guan Xin Yi Yuting Yi Lianpeng Chang Ling Yang Jialin Lv Zhirong Guo Hongyan Jia Yuxing Chu Tao Liu Ming Chen Lauren Byers Emily Roarty Vincent K. Lam Vassiliki A. Papadimitrakopoulou Ignacio Wistuba John V. Heymach Bonnie Glisson Zhongxing Liao J. Jack Lee P. Andrew Futreal Shucai Zhang Xuefeng Xia Jianjun Zhang Jinghui Wang
author_facet	Jingying Nong Yuhua Gong Yanfang Guan Xin Yi Yuting Yi Lianpeng Chang Ling Yang Jialin Lv Zhirong Guo Hongyan Jia Yuxing Chu Tao Liu Ming Chen Lauren Byers Emily Roarty Vincent K. Lam Vassiliki A. Papadimitrakopoulou Ignacio Wistuba John V. Heymach Bonnie Glisson Zhongxing Liao J. Jack Lee P. Andrew Futreal Shucai Zhang Xuefeng Xia Jianjun Zhang Jinghui Wang
author_sort	Jingying Nong
title	Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
title_short	Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
title_full	Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
title_fullStr	Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
title_full_unstemmed	Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
title_sort	circulating tumor dna analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df46aaa96e964fb0b1ab355342fd71b1
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Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer

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