Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population

Abstract Arsenic is a ubiquitous environmental toxicant with antimicrobial properties that can be found in food and drinking water. The influence of arsenic exposure on the composition of the human microbiome in US populations remains unknown, particularly during the vulnerable infant period. We inv...

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Autores principales:	Anne G. Hoen, Juliette C. Madan, Zhigang Li, Modupe Coker, Sara N. Lundgren, Hilary G. Morrison, Thomas Palys, Brian P. Jackson, Mitchell L. Sogin, Kathryn L. Cottingham, Margaret R. Karagas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df47140937674a10bf0ce4b44fe66bf2
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spelling	oai:doaj.org-article:df47140937674a10bf0ce4b44fe66bf22021-12-02T15:08:06ZSex-specific associations of infants’ gut microbiome with arsenic exposure in a US population10.1038/s41598-018-30581-92045-2322https://doaj.org/article/df47140937674a10bf0ce4b44fe66bf22018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30581-9https://doaj.org/toc/2045-2322Abstract Arsenic is a ubiquitous environmental toxicant with antimicrobial properties that can be found in food and drinking water. The influence of arsenic exposure on the composition of the human microbiome in US populations remains unknown, particularly during the vulnerable infant period. We investigated the relationship between arsenic exposure and gut microbiome composition in 204 infants prospectively followed as part of the New Hampshire Birth Cohort Study. Infant urine was analyzed for total arsenic concentration using inductively coupled plasma mass spectrometry. Stool microbiome composition was determined using sequencing of the bacterial 16S rRNA gene. Infant urinary arsenic related to gut microbiome composition at 6 weeks of life (p = 0.05, adjusted for infant feeding type and urine specific gravity). Eight genera, six within the phylum Firmicutes, were enriched with higher arsenic exposure. Fifteen genera were negatively associated with urinary arsenic concentration, including Bacteroides and Bifidobacterium. Upon stratification by both sex and feeding method, we found detectable associations among formula-fed males (p = 0.008), but not other groups (p > 0.05 for formula-fed females and for breastfed males and females). Our findings from a US population indicate that even moderate arsenic exposure may have meaningful, sex-specific effects on the gut microbiome during a critical window of infant development.Anne G. HoenJuliette C. MadanZhigang LiModupe CokerSara N. LundgrenHilary G. MorrisonThomas PalysBrian P. JacksonMitchell L. SoginKathryn L. CottinghamMargaret R. KaragasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne G. Hoen Juliette C. Madan Zhigang Li Modupe Coker Sara N. Lundgren Hilary G. Morrison Thomas Palys Brian P. Jackson Mitchell L. Sogin Kathryn L. Cottingham Margaret R. Karagas Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
description	Abstract Arsenic is a ubiquitous environmental toxicant with antimicrobial properties that can be found in food and drinking water. The influence of arsenic exposure on the composition of the human microbiome in US populations remains unknown, particularly during the vulnerable infant period. We investigated the relationship between arsenic exposure and gut microbiome composition in 204 infants prospectively followed as part of the New Hampshire Birth Cohort Study. Infant urine was analyzed for total arsenic concentration using inductively coupled plasma mass spectrometry. Stool microbiome composition was determined using sequencing of the bacterial 16S rRNA gene. Infant urinary arsenic related to gut microbiome composition at 6 weeks of life (p = 0.05, adjusted for infant feeding type and urine specific gravity). Eight genera, six within the phylum Firmicutes, were enriched with higher arsenic exposure. Fifteen genera were negatively associated with urinary arsenic concentration, including Bacteroides and Bifidobacterium. Upon stratification by both sex and feeding method, we found detectable associations among formula-fed males (p = 0.008), but not other groups (p > 0.05 for formula-fed females and for breastfed males and females). Our findings from a US population indicate that even moderate arsenic exposure may have meaningful, sex-specific effects on the gut microbiome during a critical window of infant development.
format	article
author	Anne G. Hoen Juliette C. Madan Zhigang Li Modupe Coker Sara N. Lundgren Hilary G. Morrison Thomas Palys Brian P. Jackson Mitchell L. Sogin Kathryn L. Cottingham Margaret R. Karagas
author_facet	Anne G. Hoen Juliette C. Madan Zhigang Li Modupe Coker Sara N. Lundgren Hilary G. Morrison Thomas Palys Brian P. Jackson Mitchell L. Sogin Kathryn L. Cottingham Margaret R. Karagas
author_sort	Anne G. Hoen
title	Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
title_short	Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
title_full	Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
title_fullStr	Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
title_full_unstemmed	Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
title_sort	sex-specific associations of infants’ gut microbiome with arsenic exposure in a us population
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df47140937674a10bf0ce4b44fe66bf2
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Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population

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