Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Here, the authors show that the time elapsed between Zika infection and subsequent dengue virus infection affects the magnitude and durability of the antibody and cell-mediated immune responses against dengue virus, but not viremia. This research in non-human primates has implications for co-endemic...

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Auteurs principaux: Erick X. Pérez-Guzmán, Petraleigh Pantoja, Crisanta Serrano-Collazo, Mariah A. Hassert, Alexandra Ortiz-Rosa, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Laura J. White, Melween I. Martínez, Daniela Weiskopf, James D. Brien, Aravinda de Silva, Amelia K. Pinto, Carlos A. Sariol
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/df47fefed1b64aed9ca8592422e25d1d
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Résumé:Here, the authors show that the time elapsed between Zika infection and subsequent dengue virus infection affects the magnitude and durability of the antibody and cell-mediated immune responses against dengue virus, but not viremia. This research in non-human primates has implications for co-endemic regions and vaccination.

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