AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

Summary: To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Metamorphosis is a nonfeeding stage that imposes metabolic constraints on development...

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Autores principales:	Marco Marzano, Svende Herzmann, Leonardo Elsbroek, Neeraja Sanal, Katsiaryna Tarbashevich, Erez Raz, Michael P. Krahn, Sebastian Rumpf
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	pruning dendrite AMPK translation proteasome pyruvate Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/df48f651c1e74a709cd379198c7f3ddb
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spelling	oai:doaj.org-article:df48f651c1e74a709cd379198c7f3ddb2021-11-18T04:48:01ZAMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila2211-124710.1016/j.celrep.2021.110024https://doaj.org/article/df48f651c1e74a709cd379198c7f3ddb2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721015060https://doaj.org/toc/2211-1247Summary: To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Metamorphosis is a nonfeeding stage that imposes metabolic constraints on development. We find that AMP-activated protein kinase (AMPK), a regulator of energy homeostasis, is cell-autonomously required for dendrite pruning. AMPK is activated by ecdysone and promotes oxidative phosphorylation and pyruvate usage, likely to enable neurons to use noncarbohydrate metabolites such as amino acids for energy production. Loss of AMPK or mitochondrial deficiency causes specific defects in pruning factor translation and the ubiquitin-proteasome system. Our findings distinguish pruning from pathological neurite degeneration, which is often induced by defects in energy production, and highlight how metabolism is adapted to fit energy-costly developmental transitions.Marco MarzanoSvende HerzmannLeonardo ElsbroekNeeraja SanalKatsiaryna TarbashevichErez RazMichael P. KrahnSebastian RumpfElsevierarticlepruningdendriteAMPKtranslationproteasomepyruvateBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 7, Pp 110024- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pruning dendrite AMPK translation proteasome pyruvate Biology (General) QH301-705.5
spellingShingle	pruning dendrite AMPK translation proteasome pyruvate Biology (General) QH301-705.5 Marco Marzano Svende Herzmann Leonardo Elsbroek Neeraja Sanal Katsiaryna Tarbashevich Erez Raz Michael P. Krahn Sebastian Rumpf AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
description	Summary: To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Metamorphosis is a nonfeeding stage that imposes metabolic constraints on development. We find that AMP-activated protein kinase (AMPK), a regulator of energy homeostasis, is cell-autonomously required for dendrite pruning. AMPK is activated by ecdysone and promotes oxidative phosphorylation and pyruvate usage, likely to enable neurons to use noncarbohydrate metabolites such as amino acids for energy production. Loss of AMPK or mitochondrial deficiency causes specific defects in pruning factor translation and the ubiquitin-proteasome system. Our findings distinguish pruning from pathological neurite degeneration, which is often induced by defects in energy production, and highlight how metabolism is adapted to fit energy-costly developmental transitions.
format	article
author	Marco Marzano Svende Herzmann Leonardo Elsbroek Neeraja Sanal Katsiaryna Tarbashevich Erez Raz Michael P. Krahn Sebastian Rumpf
author_facet	Marco Marzano Svende Herzmann Leonardo Elsbroek Neeraja Sanal Katsiaryna Tarbashevich Erez Raz Michael P. Krahn Sebastian Rumpf
author_sort	Marco Marzano
title	AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
title_short	AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
title_full	AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
title_fullStr	AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
title_full_unstemmed	AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila
title_sort	ampk adapts metabolism to developmental energy requirement during dendrite pruning in drosophila
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/df48f651c1e74a709cd379198c7f3ddb
work_keys_str_mv	AT marcomarzano ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT svendeherzmann ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT leonardoelsbroek ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT neerajasanal ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT katsiarynatarbashevich ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT erezraz ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT michaelpkrahn ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila AT sebastianrumpf ampkadaptsmetabolismtodevelopmentalenergyrequirementduringdendritepruningindrosophila
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AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

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