Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.

Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was...

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Autores principales:	Jiwang Chen, Esther S Wilson, Mary K Dahmer, Michael W Quasney, Grant W Waterer, Charles Feldman, Richard G Wunderink
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df4b55365a46452d85f83dd85964727a
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spelling	oai:doaj.org-article:df4b55365a46452d85f83dd85964727a2021-11-18T08:30:57ZLack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.1932-620310.1371/journal.pone.0089194https://doaj.org/article/df4b55365a46452d85f83dd85964727a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586588/?tool=EBIhttps://doaj.org/toc/1932-6203Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was a marker for susceptibility and/or severity of CAP. We examined three CAP cohorts and two control populations: 241 adult Memphis African American CAP patients, 443 pediatric African American CAP patients, 90 adult South African CAP patients, 120 Memphis healthy adult African American controls and 405 adult Chicago African American controls. Clinical outcomes including mortality, acute respiratory distress syndrome (ARDS), septic shock or severe sepsis, need for mechanical ventilation, and S. pneumoniae bacteremia. Neither in the three individual CAP cohorts nor in the combined CAP cohorts, was mortality in CASP12L carriers significantly different from that in non-CASP12L carriers. No statistically significant association between genotype and any measures of CAP severity was found in any cohort. We conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP.Jiwang ChenEsther S WilsonMary K DahmerMichael W QuasneyGrant W WatererCharles FeldmanRichard G WunderinkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89194 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiwang Chen Esther S Wilson Mary K Dahmer Michael W Quasney Grant W Waterer Charles Feldman Richard G Wunderink Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
description	Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was a marker for susceptibility and/or severity of CAP. We examined three CAP cohorts and two control populations: 241 adult Memphis African American CAP patients, 443 pediatric African American CAP patients, 90 adult South African CAP patients, 120 Memphis healthy adult African American controls and 405 adult Chicago African American controls. Clinical outcomes including mortality, acute respiratory distress syndrome (ARDS), septic shock or severe sepsis, need for mechanical ventilation, and S. pneumoniae bacteremia. Neither in the three individual CAP cohorts nor in the combined CAP cohorts, was mortality in CASP12L carriers significantly different from that in non-CASP12L carriers. No statistically significant association between genotype and any measures of CAP severity was found in any cohort. We conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP.
format	article
author	Jiwang Chen Esther S Wilson Mary K Dahmer Michael W Quasney Grant W Waterer Charles Feldman Richard G Wunderink
author_facet	Jiwang Chen Esther S Wilson Mary K Dahmer Michael W Quasney Grant W Waterer Charles Feldman Richard G Wunderink
author_sort	Jiwang Chen
title	Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
title_short	Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
title_full	Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
title_fullStr	Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
title_full_unstemmed	Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
title_sort	lack of association of the caspase-12 long allele with community-acquired pneumonia in people of african descent.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/df4b55365a46452d85f83dd85964727a
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Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.

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