Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging

Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging

Li-Wen Chang,1 Mei-Ling Hou,1 Shuo-Hui Hung,2 Lie-Chwen Lin,3 Tung-Hu Tsai1,4–6 1Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 2Department of Surgery, 3National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 4Departm...

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Autores principales: Chang LW, Hou ML, Hung SH, Lin LC, Tsai TH
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/df578320f1b54aab893325fa539ad472
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spelling oai:doaj.org-article:df578320f1b54aab893325fa539ad4722021-12-02T03:58:36ZPharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging1178-2013https://doaj.org/article/df578320f1b54aab893325fa539ad4722015-04-01T00:00:00Zhttp://www.dovepress.com/pharmacokinetics-of-quercetin-loaded-nanodroplets-with-ultrasound-acti-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Li-Wen Chang,1 Mei-Ling Hou,1 Shuo-Hui Hung,2 Lie-Chwen Lin,3 Tung-Hu Tsai1,4–6 1Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 2Department of Surgery, 3National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 4Department of Education and Research, Taipei City Hospital, 5School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 6Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan Abstract: Bubble formulations have both diagnostic and therapeutic applications. However, research on nanobubbles/nanodroplets remains in the initial stages. In this study, a nanodroplet formulation was prepared and loaded with a novel class of chemotherapeutic drug, ie, quercetin, to observe its pharmacokinetic properties and ultrasonic bioimaging of specific sites, namely the abdominal vein and bladder. Four parallel groups were designed to investigate the effects of ultrasound and nanodroplets on the pharmacokinetics of quercetin. These groups were quercetin alone, quercetin triggered with ultrasound, quercetin-encapsulated in nanodroplets, and quercetin encapsulated in nanodroplets triggered with ultrasound. Spherical vesicles with a mean diameter of 280 nm were formed, and quercetin was completely encapsulated within. In vivo ultrasonic imaging confirmed that the nanodroplets could be treated by ultrasound. The results indicate that the initial 5-minute serum concentration, area under the concentration–time curve, elimination half-life, and clearance of quercetin were significantly enhanced by nanodroplets with or without ultrasound. Keywords: nanodroplets, quercetin, ultrasonic pharmacokinetics, ultrasonic imaging, ultrasoundChang LWHou MLHung SHLin LCTsai THDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3031-3042 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Chang LW
Hou ML
Hung SH
Lin LC
Tsai TH
Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
description Li-Wen Chang,1 Mei-Ling Hou,1 Shuo-Hui Hung,2 Lie-Chwen Lin,3 Tung-Hu Tsai1,4–6 1Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 2Department of Surgery, 3National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 4Department of Education and Research, Taipei City Hospital, 5School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 6Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan Abstract: Bubble formulations have both diagnostic and therapeutic applications. However, research on nanobubbles/nanodroplets remains in the initial stages. In this study, a nanodroplet formulation was prepared and loaded with a novel class of chemotherapeutic drug, ie, quercetin, to observe its pharmacokinetic properties and ultrasonic bioimaging of specific sites, namely the abdominal vein and bladder. Four parallel groups were designed to investigate the effects of ultrasound and nanodroplets on the pharmacokinetics of quercetin. These groups were quercetin alone, quercetin triggered with ultrasound, quercetin-encapsulated in nanodroplets, and quercetin encapsulated in nanodroplets triggered with ultrasound. Spherical vesicles with a mean diameter of 280 nm were formed, and quercetin was completely encapsulated within. In vivo ultrasonic imaging confirmed that the nanodroplets could be treated by ultrasound. The results indicate that the initial 5-minute serum concentration, area under the concentration–time curve, elimination half-life, and clearance of quercetin were significantly enhanced by nanodroplets with or without ultrasound. Keywords: nanodroplets, quercetin, ultrasonic pharmacokinetics, ultrasonic imaging, ultrasound
format article
author Chang LW
Hou ML
Hung SH
Lin LC
Tsai TH
author_facet Chang LW
Hou ML
Hung SH
Lin LC
Tsai TH
author_sort Chang LW
title Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
title_short Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
title_full Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
title_fullStr Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
title_full_unstemmed Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
title_sort pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/df578320f1b54aab893325fa539ad472
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AT hungsh pharmacokineticsofquercetinloadednanodropletswithultrasoundactivationandnbsptheirnbspuseforbioimaging
AT linlc pharmacokineticsofquercetinloadednanodropletswithultrasoundactivationandnbsptheirnbspuseforbioimaging
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