Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies

Xun Jin,1 Peilan Zhang,1 Li Luo,1 Hao Cheng,1 Yunzu Li,1 Ting Du,1 Bingwen Zou,2 Maling Gou1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2Department...

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Autores principales:	Jin X, Zhang P, Luo L, Cheng H, Li Y, Du T, Zou B, Gou M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Bladder cancer Drug delivery Nanoparticles Intravesical therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/df586edb1eca459b85ac37591112e400
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spelling	oai:doaj.org-article:df586edb1eca459b85ac37591112e4002021-12-02T02:10:26ZEfficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies1178-2013https://doaj.org/article/df586edb1eca459b85ac37591112e4002016-09-01T00:00:00Zhttps://www.dovepress.com/efficient-intravesical-therapy-of-bladder-cancer-with-cationic-doxorub-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xun Jin,1 Peilan Zhang,1 Li Luo,1 Hao Cheng,1 Yunzu Li,1 Ting Du,1 Bingwen Zou,2 Maling Gou1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2Department of Thoracic Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China Abstract: Nanoparticles have promising applications in drug delivery for cancer therapy. Herein, we prepared cationic 1,2-dioleoyl-3-trimethylammonium propane/methoxypoly (ethyleneglycol) (DPP) nanoparticles to deliver doxorubicin (Dox) for intravesical therapy of bladder cancer. The DPP micelles have a mean dynamic diameter of 18.65 nm and a mean zeta potential of +19.6 mV. The DPP micelles could prolong the residence of Dox in the bladder, enhance the penetration of Dox into the bladder wall, and improve cellular uptake of Dox. The encapsulation by DPP micelles significantly improved the anticancer effect of Dox against orthotopic bladder cancer in vivo. This work described a Dox-loaded DPP nanoparticle with potential applications in intravesical therapy of bladder cancer. Keywords: bladder cancer, drug delivery, nanoparticles, intravesical therapyJin XZhang PLuo LCheng HLi YDu TZou BGou MDove Medical PressarticleBladder cancerDrug deliveryNanoparticlesIntravesical therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4535-4544 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bladder cancer Drug delivery Nanoparticles Intravesical therapy Medicine (General) R5-920
spellingShingle	Bladder cancer Drug delivery Nanoparticles Intravesical therapy Medicine (General) R5-920 Jin X Zhang P Luo L Cheng H Li Y Du T Zou B Gou M Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
description	Xun Jin,1 Peilan Zhang,1 Li Luo,1 Hao Cheng,1 Yunzu Li,1 Ting Du,1 Bingwen Zou,2 Maling Gou1 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China; 2Department of Thoracic Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China Abstract: Nanoparticles have promising applications in drug delivery for cancer therapy. Herein, we prepared cationic 1,2-dioleoyl-3-trimethylammonium propane/methoxypoly (ethyleneglycol) (DPP) nanoparticles to deliver doxorubicin (Dox) for intravesical therapy of bladder cancer. The DPP micelles have a mean dynamic diameter of 18.65 nm and a mean zeta potential of +19.6 mV. The DPP micelles could prolong the residence of Dox in the bladder, enhance the penetration of Dox into the bladder wall, and improve cellular uptake of Dox. The encapsulation by DPP micelles significantly improved the anticancer effect of Dox against orthotopic bladder cancer in vivo. This work described a Dox-loaded DPP nanoparticle with potential applications in intravesical therapy of bladder cancer. Keywords: bladder cancer, drug delivery, nanoparticles, intravesical therapy
format	article
author	Jin X Zhang P Luo L Cheng H Li Y Du T Zou B Gou M
author_facet	Jin X Zhang P Luo L Cheng H Li Y Du T Zou B Gou M
author_sort	Jin X
title	Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
title_short	Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
title_full	Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
title_fullStr	Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
title_full_unstemmed	Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
title_sort	efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/df586edb1eca459b85ac37591112e400
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Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies

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