Ethanol exposure increases mutation rate through error-prone polymerases

Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.

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Autores principales:	Karin Voordeckers, Camilla Colding, Lavinia Grasso, Benjamin Pardo, Lore Hoes, Jacek Kominek, Kim Gielens, Kaat Dekoster, Jonathan Gordon, Elisa Van der Zande, Peter Bircham, Toon Swings, Jan Michiels, Peter Van Loo, Sandra Nuyts, Philippe Pasero, Michael Lisby, Kevin J. Verstrepen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df587fed078742dfbc9ad32716f400df
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spelling	oai:doaj.org-article:df587fed078742dfbc9ad32716f400df2021-12-02T16:17:53ZEthanol exposure increases mutation rate through error-prone polymerases10.1038/s41467-020-17447-32041-1723https://doaj.org/article/df587fed078742dfbc9ad32716f400df2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17447-3https://doaj.org/toc/2041-1723Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.Karin VoordeckersCamilla ColdingLavinia GrassoBenjamin PardoLore HoesJacek KominekKim GielensKaat DekosterJonathan GordonElisa Van der ZandePeter BirchamToon SwingsJan MichielsPeter Van LooSandra NuytsPhilippe PaseroMichael LisbyKevin J. VerstrepenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karin Voordeckers Camilla Colding Lavinia Grasso Benjamin Pardo Lore Hoes Jacek Kominek Kim Gielens Kaat Dekoster Jonathan Gordon Elisa Van der Zande Peter Bircham Toon Swings Jan Michiels Peter Van Loo Sandra Nuyts Philippe Pasero Michael Lisby Kevin J. Verstrepen Ethanol exposure increases mutation rate through error-prone polymerases
description	Whereas the toxic effects of ethanol are well-documented, the underlying mechanism is obscure. This study uses the eukaryotic model S. cerevisiae to reveal how exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.
format	article
author	Karin Voordeckers Camilla Colding Lavinia Grasso Benjamin Pardo Lore Hoes Jacek Kominek Kim Gielens Kaat Dekoster Jonathan Gordon Elisa Van der Zande Peter Bircham Toon Swings Jan Michiels Peter Van Loo Sandra Nuyts Philippe Pasero Michael Lisby Kevin J. Verstrepen
author_facet	Karin Voordeckers Camilla Colding Lavinia Grasso Benjamin Pardo Lore Hoes Jacek Kominek Kim Gielens Kaat Dekoster Jonathan Gordon Elisa Van der Zande Peter Bircham Toon Swings Jan Michiels Peter Van Loo Sandra Nuyts Philippe Pasero Michael Lisby Kevin J. Verstrepen
author_sort	Karin Voordeckers
title	Ethanol exposure increases mutation rate through error-prone polymerases
title_short	Ethanol exposure increases mutation rate through error-prone polymerases
title_full	Ethanol exposure increases mutation rate through error-prone polymerases
title_fullStr	Ethanol exposure increases mutation rate through error-prone polymerases
title_full_unstemmed	Ethanol exposure increases mutation rate through error-prone polymerases
title_sort	ethanol exposure increases mutation rate through error-prone polymerases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/df587fed078742dfbc9ad32716f400df
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Ethanol exposure increases mutation rate through error-prone polymerases

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