Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to p...

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Auteurs principaux:	Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto, Yasuhito Onodera, Shotaro Furukawa, Haruka Handa, Tsukasa Oikawa, Yasunori Okada, Mototsugu Oya, Hisataka Sabe
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab
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spelling	oai:doaj.org-article:df5d72ff58b24394a6c880e7d14b9eab2021-12-02T16:57:50ZLysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer10.1038/ncomms106562041-1723https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10656https://doaj.org/toc/2041-1723Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to promote invasion, metastasis and drug resistance.Shigeru HashimotoShuji MikamiHirokazu SuginoAyumu YoshikawaAri HashimotoYasuhito OnoderaShotaro FurukawaHaruka HandaTsukasa OikawaYasunori OkadaMototsugu OyaHisataka SabeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shigeru Hashimoto Shuji Mikami Hirokazu Sugino Ayumu Yoshikawa Ari Hashimoto Yasuhito Onodera Shotaro Furukawa Haruka Handa Tsukasa Oikawa Yasunori Okada Mototsugu Oya Hisataka Sabe Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
description	Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to promote invasion, metastasis and drug resistance.
format	article
author	Shigeru Hashimoto Shuji Mikami Hirokazu Sugino Ayumu Yoshikawa Ari Hashimoto Yasuhito Onodera Shotaro Furukawa Haruka Handa Tsukasa Oikawa Yasunori Okada Mototsugu Oya Hisataka Sabe
author_facet	Shigeru Hashimoto Shuji Mikami Hirokazu Sugino Ayumu Yoshikawa Ari Hashimoto Yasuhito Onodera Shotaro Furukawa Haruka Handa Tsukasa Oikawa Yasunori Okada Mototsugu Oya Hisataka Sabe
author_sort	Shigeru Hashimoto
title	Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_short	Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_full	Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_fullStr	Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_full_unstemmed	Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_sort	lysophosphatidic acid activates arf6 to promote the mesenchymal malignancy of renal cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab
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Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

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