Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to p...

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Autores principales: Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto, Yasuhito Onodera, Shotaro Furukawa, Haruka Handa, Tsukasa Oikawa, Yasunori Okada, Mototsugu Oya, Hisataka Sabe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab
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spelling oai:doaj.org-article:df5d72ff58b24394a6c880e7d14b9eab2021-12-02T16:57:50ZLysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer10.1038/ncomms106562041-1723https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10656https://doaj.org/toc/2041-1723Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to promote invasion, metastasis and drug resistance.Shigeru HashimotoShuji MikamiHirokazu SuginoAyumu YoshikawaAri HashimotoYasuhito OnoderaShotaro FurukawaHaruka HandaTsukasa OikawaYasunori OkadaMototsugu OyaHisataka SabeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shigeru Hashimoto
Shuji Mikami
Hirokazu Sugino
Ayumu Yoshikawa
Ari Hashimoto
Yasuhito Onodera
Shotaro Furukawa
Haruka Handa
Tsukasa Oikawa
Yasunori Okada
Mototsugu Oya
Hisataka Sabe
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
description Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to promote invasion, metastasis and drug resistance.
format article
author Shigeru Hashimoto
Shuji Mikami
Hirokazu Sugino
Ayumu Yoshikawa
Ari Hashimoto
Yasuhito Onodera
Shotaro Furukawa
Haruka Handa
Tsukasa Oikawa
Yasunori Okada
Mototsugu Oya
Hisataka Sabe
author_facet Shigeru Hashimoto
Shuji Mikami
Hirokazu Sugino
Ayumu Yoshikawa
Ari Hashimoto
Yasuhito Onodera
Shotaro Furukawa
Haruka Handa
Tsukasa Oikawa
Yasunori Okada
Mototsugu Oya
Hisataka Sabe
author_sort Shigeru Hashimoto
title Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_short Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_full Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_fullStr Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_full_unstemmed Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
title_sort lysophosphatidic acid activates arf6 to promote the mesenchymal malignancy of renal cancer
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/df5d72ff58b24394a6c880e7d14b9eab
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