Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas

Paragangliomas are rare neuroendocrine tumors that can vary in size and metabolic activity. We report a case of giant bilateral malignant retroperitoneal paragangliomas (PGL) in a patient with germline succinate dehydrogenase B (SDHB) mutation. This patient, who presented in an emaciated and debilit...

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Autores principales:	David Strauss, Andres Correa, Yulan Gong, Andreas Karachristos, Alexander Kutikov
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Retroperitoneal Giant paraganglioma Succinate dehydrogenase mutation Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/df5fdb05953c404eb70c4b417988e9fb
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spelling	oai:doaj.org-article:df5fdb05953c404eb70c4b417988e9fb2021-12-04T04:34:18ZManagement of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas2214-442010.1016/j.eucr.2021.101950https://doaj.org/article/df5fdb05953c404eb70c4b417988e9fb2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214442021003909https://doaj.org/toc/2214-4420Paragangliomas are rare neuroendocrine tumors that can vary in size and metabolic activity. We report a case of giant bilateral malignant retroperitoneal paragangliomas (PGL) in a patient with germline succinate dehydrogenase B (SDHB) mutation. This patient, who presented in an emaciated and debilitated state, was managed with adrenergic blockade followed by radical primary surgery. After being metabolically and radiographically disease free for 4 years, he underwent salvage resection for recurrent retroperitoneal disease and palliative radiation to a site of solidary vertebral metastasis. We review incidence and prognosis of metastatic PGL.David StraussAndres CorreaYulan GongAndreas KarachristosAlexander KutikovElsevierarticleRetroperitonealGiant paragangliomaSuccinate dehydrogenase mutationDiseases of the genitourinary system. UrologyRC870-923ENUrology Case Reports, Vol 40, Iss , Pp 101950- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Retroperitoneal Giant paraganglioma Succinate dehydrogenase mutation Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Retroperitoneal Giant paraganglioma Succinate dehydrogenase mutation Diseases of the genitourinary system. Urology RC870-923 David Strauss Andres Correa Yulan Gong Andreas Karachristos Alexander Kutikov Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
description	Paragangliomas are rare neuroendocrine tumors that can vary in size and metabolic activity. We report a case of giant bilateral malignant retroperitoneal paragangliomas (PGL) in a patient with germline succinate dehydrogenase B (SDHB) mutation. This patient, who presented in an emaciated and debilitated state, was managed with adrenergic blockade followed by radical primary surgery. After being metabolically and radiographically disease free for 4 years, he underwent salvage resection for recurrent retroperitoneal disease and palliative radiation to a site of solidary vertebral metastasis. We review incidence and prognosis of metastatic PGL.
format	article
author	David Strauss Andres Correa Yulan Gong Andreas Karachristos Alexander Kutikov
author_facet	David Strauss Andres Correa Yulan Gong Andreas Karachristos Alexander Kutikov
author_sort	David Strauss
title	Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
title_short	Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
title_full	Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
title_fullStr	Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
title_full_unstemmed	Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas
title_sort	management of shdb positive patient with metastatic bilateral giant retroperitoneal paragangliomas
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/df5fdb05953c404eb70c4b417988e9fb
work_keys_str_mv	AT davidstrauss managementofshdbpositivepatientwithmetastaticbilateralgiantretroperitonealparagangliomas AT andrescorrea managementofshdbpositivepatientwithmetastaticbilateralgiantretroperitonealparagangliomas AT yulangong managementofshdbpositivepatientwithmetastaticbilateralgiantretroperitonealparagangliomas AT andreaskarachristos managementofshdbpositivepatientwithmetastaticbilateralgiantretroperitonealparagangliomas AT alexanderkutikov managementofshdbpositivepatientwithmetastaticbilateralgiantretroperitonealparagangliomas
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Management of SHDB positive patient with metastatic bilateral giant retroperitoneal paragangliomas

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